Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.toxicon.2007.11.019
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dc.titleAntioxidants: Promising neuroprotection against cardiotoxin-4b-induced cell death which triggers oxidative stress with early calpain activation
dc.contributor.authorToh, T.B.
dc.contributor.authorChen, M.J.
dc.contributor.authorArmugam, A.
dc.contributor.authorLi, Q.-T.
dc.contributor.authorJeyaseelan, K.
dc.contributor.authorCheung, N.S.
dc.contributor.authorPeng, Z.F.
dc.date.accessioned2011-11-29T06:09:40Z
dc.date.available2011-11-29T06:09:40Z
dc.date.issued2008
dc.identifier.citationToh, T.B., Chen, M.J., Armugam, A., Li, Q.-T., Jeyaseelan, K., Cheung, N.S., Peng, Z.F. (2008). Antioxidants: Promising neuroprotection against cardiotoxin-4b-induced cell death which triggers oxidative stress with early calpain activation. Toxicon 51 (6) : 964-973. ScholarBank@NUS Repository. https://doi.org/10.1016/j.toxicon.2007.11.019
dc.identifier.issn00410101
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/28804
dc.description.abstractCardiotoxin-4b (CTX-4b), isolated from Naja naja sputatrix venom, shows lethality in several cell types. Employing murine primary cortical neurons, this study was undertaken to investigate the molecular mechanisms of CTX-4b in the induction of neuronal death. CTX-4b induced a dose- and time-dependent neuronal death. Strong induction of calpains as early as 4 h post-CTX-4b 75 nM treatment was detected in neurons with negligible caspase 3 activation. For the first time in cultured murine primary cortical neurons, it was noted that CTX-4b-mediated cell death triggered oxidative stress with an increase in reactive oxygen species (ROS) levels, and that application of antioxidants showed effective attenuation of cell death. Taken together, these results indicate that CTX-4b-mediated neuronal death is associated with (i) early calpain activation and (ii) oxidative stress. Most importantly, antioxidants have proved to be a promising therapeutic avenue against CTX-4b-induced neuronal death. © 2007 Elsevier Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.toxicon.2007.11.019
dc.sourceScopus
dc.subjectCardiotoxins
dc.subjectCTX-4b
dc.subjectNeuronal death
dc.subjectOxidative stress
dc.subjectROS
dc.typeArticle
dc.contributor.departmentBIOCHEMISTRY
dc.contributor.departmentPHARMACOLOGY
dc.description.doi10.1016/j.toxicon.2007.11.019
dc.description.sourcetitleToxicon
dc.description.volume51
dc.description.issue6
dc.description.page964-973
dc.description.codenTOXIA
dc.identifier.isiut000256500300003
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