Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.cellimm.2007.02.005
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dc.titleA systematic bioinformatics approach for selection of epitope-based vaccine targets
dc.contributor.authorKhan, A.M.
dc.contributor.authorBrusic, V.
dc.contributor.authorMiotto, O.
dc.contributor.authorHeiny, A.T.
dc.contributor.authorTan, T.W.
dc.contributor.authorSalmon, J.
dc.contributor.authorSrinivasan, K.N.
dc.contributor.authorMarques, Jr. E.T.A.
dc.contributor.authorAugust, J.T.
dc.contributor.authorNascimento, E.J.M.
dc.date.accessioned2011-11-29T06:09:31Z
dc.date.available2011-11-29T06:09:31Z
dc.date.issued2006
dc.identifier.citationKhan, A.M., Brusic, V., Miotto, O., Heiny, A.T., Tan, T.W., Salmon, J., Srinivasan, K.N., Marques, Jr. E.T.A., August, J.T., Nascimento, E.J.M. (2006). A systematic bioinformatics approach for selection of epitope-based vaccine targets. Cellular Immunology 244 (2) : 141-147. ScholarBank@NUS Repository. https://doi.org/10.1016/j.cellimm.2007.02.005
dc.identifier.issn00088749
dc.identifier.issn10902163
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/28792
dc.description.abstractEpitope-based vaccines provide a new strategy for prophylactic and therapeutic application of pathogen-specific immunity. A critical requirement of this strategy is the identification and selection of T-cell epitopes that act as vaccine targets. This study describes current methodologies for the selection process, with dengue virus as a model system. A combination of publicly available bioinformatics algorithms and computational tools are used to screen and select antigen sequences as potential T-cell epitopes of supertype human leukocyte antigen (HLA) alleles. The selected sequences are tested for biological function by their activation of T-cells of HLA transgenic mice and of pathogen infected subjects. This approach provides an experimental basis for the design of pathogen specific, T-cell epitope-based vaccines that are targeted to majority of the genetic variants of the pathogen, and are effective for a broad range of differences in human leukocyte antigens among the global human population. © 2007 Elsevier Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.cellimm.2007.02.005
dc.sourceScopus
dc.subjectAltered-ligand effect
dc.subjectBioinformatics
dc.subjectConserved sequences
dc.subjectEpitope-based vaccines
dc.subjectImmune system
dc.subjectImmunological hotspots
dc.subjectInformation entropy
dc.subjectPathogens
dc.subjectSupertypes
dc.subjectT-cell epitopes
dc.typeArticle
dc.contributor.departmentBIOCHEMISTRY
dc.contributor.departmentINSTITUTE OF SYSTEMS SCIENCE
dc.contributor.departmentMICROBIOLOGY
dc.description.doi10.1016/j.cellimm.2007.02.005
dc.description.sourcetitleCellular Immunology
dc.description.volume244
dc.description.issue2
dc.description.page141-147
dc.description.codenCLIMB
dc.identifier.isiut000246776700015
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