Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.neurobiolaging.2005.02.001
DC FieldValue
dc.titleSIRT1, neuronal cell survival and the insulin/IGF-1 aging paradox
dc.contributor.authorTang, B.L.
dc.date.accessioned2011-11-29T05:59:17Z
dc.date.available2011-11-29T05:59:17Z
dc.date.issued2006
dc.identifier.citationTang, B.L. (2006). SIRT1, neuronal cell survival and the insulin/IGF-1 aging paradox. Neurobiology of Aging 27 (3) : 501-505. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neurobiolaging.2005.02.001
dc.identifier.issn01974580
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/28775
dc.description.abstractSignaling through the insulin/IGF-1 pro-survival pathway is widely recognized to be neuroprotective as well as important for neuronal growth and physiology. In mammals, age-associated decline in circulating IGF-1 levels has been associated with neuronal aging and symptoms of neurodegeneration. Defects in IGF-1 receptor associated signaling has, however, been shown to significantly extend lifespan in models ranging from invertebrates to mouse. At least in C. elegans, restoring such defects in neurons alone reduces lifespan to wild-type levels. As we seek to delay brain aging and age-associated neuronal degeneration via nutritional and endocrinal supplements, an understanding of the mechanistic basis of this apparent paradox is important. Recent elucidation of the role of the protein deacetylase SIRT1 in cell survival and data associating IGF-1 with the regulation of SIRT1 expression may provide a direction towards resolving this issue. © 2005 Elsevier Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.neurobiolaging.2005.02.001
dc.sourceScopus
dc.subjectApoptosis
dc.subjectIGF-1
dc.subjectNeurons
dc.subjectSir2
dc.subjectSIRT1
dc.typeReview
dc.contributor.departmentBIOCHEMISTRY
dc.description.doi10.1016/j.neurobiolaging.2005.02.001
dc.description.sourcetitleNeurobiology of Aging
dc.description.volume27
dc.description.issue3
dc.description.page501-505
dc.description.codenNEAGD
dc.identifier.isiut000235755400015
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