Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.mam.2007.02.001
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dc.titleSIRT1 and neuronal diseases
dc.contributor.authorTang, B.L.
dc.contributor.authorChua, C.E.L.
dc.date.accessioned2011-11-29T05:59:16Z
dc.date.available2011-11-29T05:59:16Z
dc.date.issued2008
dc.identifier.citationTang, B.L., Chua, C.E.L. (2008). SIRT1 and neuronal diseases. Molecular Aspects of Medicine 29 (3) : 187-200. ScholarBank@NUS Repository. https://doi.org/10.1016/j.mam.2007.02.001
dc.identifier.issn00982997
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/28774
dc.description.abstractSIRT1 is the mammalian homologue of yeast silent information regulator (Sir)-2, a member of the sirtuin family of protein deacetylases which have gained much attention as mediators of lifespan extension in several model organisms. Induction of SIRT1 expression also attenuates neuronal degeneration and death in animal models of Alzheimer's disease and Huntington's disease. SIRT1 induction, either by sirtuin activators such as resveratrol, or metabolic conditioning associated with caloric restriction (CR), could be neuroprotective in several ways. It could promote the non-amyloidogenic cleavage of the amyloid precursor protein, enhance clearance of amyloid β-peptides, and reduced neuronal damage through potential inhibition of neuroinflammatory signaling pathways. In addition, increased SIRT1 activity could alter neuronal transcription profiles to enhance anti-stress and anti-apoptotic gene activities, and has been proposed to underlie the inhibition of axonal degeneration in the Wallerian degeneration slow (Wlds) phenotype. As neuronal degeneration is a major pathophysiological aspect of human aging, understanding the mechanism of SIRT1 neuroprotection promises novel strategies in clinical intervention of neurodegenerative diseases. © 2007 Elsevier Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.mam.2007.02.001
dc.sourceScopus
dc.subjectAlzheimer's disease
dc.subjectHuntington's disease
dc.subjectNeurodegeneration
dc.subjectNeuron
dc.subjectSIRT1
dc.subjectSirtuin
dc.typeReview
dc.contributor.departmentBIOCHEMISTRY
dc.description.doi10.1016/j.mam.2007.02.001
dc.description.sourcetitleMolecular Aspects of Medicine
dc.description.volume29
dc.description.issue3
dc.description.page187-200
dc.description.codenMAMED
dc.identifier.isiut000256643800002
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