Please use this identifier to cite or link to this item:
|Title:||Rab35 - A vesicular traffic-regulating small GTPase with actin modulating roles||Authors:||Chua, C.E.L.
|Issue Date:||2010||Citation:||Chua, C.E.L., Lim, Y.S., Tang, B.L. (2010). Rab35 - A vesicular traffic-regulating small GTPase with actin modulating roles. FEBS Letters 584 (1) : 1-6. ScholarBank@NUS Repository. https://doi.org/10.1016/j.febslet.2009.11.051||Abstract:||The Rab family of GTPases are regulators of eukaryotic vesicular membrane traffic, while modulation of actin dynamics is a function conventionally associated with the Rho family of GTPases. Rab35 is a Rab protein with both plasma membrane and endosomal localization, and has been implicated in diverse processes that include T-cell receptor recycling, oocyte yolk protein recycling and cytokinesis. Rab35 regulates neurite outgrowth in neuronal-like cells, and can induce protrusions even in typically non-adherent Jurkat T-cells. Recent evidence indicates that Rab35's activity, particularly the ability to mediate protrusive outgrowths, is due to its direct influence on actin dynamics. This can occur via activation of the Rho family of GTPases, or through the engagement of its effector fascin, an actin bundling protein. © 2009 Federation of European Biochemical Societies.||Source Title:||FEBS Letters||URI:||http://scholarbank.nus.edu.sg/handle/10635/28768||ISSN:||00145793||DOI:||10.1016/j.febslet.2009.11.051|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Aug 15, 2019
WEB OF SCIENCETM
checked on Aug 8, 2019
checked on Aug 19, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.