Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.brainresrev.2008.04.006
DC FieldValue
dc.titleRab GTPases and their roles in brain neurons and glia
dc.contributor.authorNg, E.L.
dc.contributor.authorTang, B.L.
dc.date.accessioned2011-11-29T05:59:12Z
dc.date.available2011-11-29T05:59:12Z
dc.date.issued2008
dc.identifier.citationNg, E.L., Tang, B.L. (2008). Rab GTPases and their roles in brain neurons and glia. Brain Research Reviews 58 (1) : 236-246. ScholarBank@NUS Repository. https://doi.org/10.1016/j.brainresrev.2008.04.006
dc.identifier.issn01650173
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/28767
dc.description.abstractThe Rab family of small GTPases serves as cellular regulators of vesicular transport in all eukaryotes. Higher organisms have a vastly expanded number of Rabs. Some of these would presumably perform cell-type or tissue-specific functions. Roles for Rab proteins in several aspects of cellular physiology that are peculiar to neurons have been revealed. Rabs, in conjunction with their effectors and regulators, participate in central nervous system development (Rab23), polarized neurite growth (Rab8 and Rab11), endocytosis and axonal retrograde transport (Rab5 and Rab7). At chemical synapses, Rabs perform specific functions in synaptic vesicle exocytosis (Rab3) and postsynaptic compartment dynamics of glutamate receptors (Rab8). Much less is known about the role of Rabs in astroglia/oligodendroglia-specific processes, although Rab family members that are glia-enriched (Rab22B, Rab40C) have been reported. We summarized and discussed recent findings on the roles played by Rabs in neurons and glia in the central nervous system, and speculate on future directions. © 2008 Elsevier B.V. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.brainresrev.2008.04.006
dc.sourceScopus
dc.subjectAxonal transport
dc.subjectEndocytosis
dc.subjectGlia
dc.subjectNeuron
dc.subjectRab
dc.subjectSynapse
dc.typeReview
dc.contributor.departmentBIOCHEMISTRY
dc.description.doi10.1016/j.brainresrev.2008.04.006
dc.description.sourcetitleBrain Research Reviews
dc.description.volume58
dc.description.issue1
dc.description.page236-246
dc.description.codenBRERD
dc.identifier.isiut000257837800017
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