Please use this identifier to cite or link to this item:
Title: Environmental enrichment and neurodegenerative diseases
Authors: Li, L.
Bor, L.T. 
Keywords: Alzheimer's disease
Environmental enrichment
Huntington's disease
Parkinson's disease
Issue Date: 2005
Citation: Li, L., Bor, L.T. (2005). Environmental enrichment and neurodegenerative diseases. Biochemical and Biophysical Research Communications 334 (2) : 293-297. ScholarBank@NUS Repository.
Abstract: Recent reports on experimental models of neurodegeneration in mice have strengthened the notion that environmental enrichment (EE) is beneficial, in terms of delayed onset and progression, to a variety of neurodegenerative diseases. These studies also revealed interesting mechanistic understandings as to how EE might function. While it is generally assumed that EE elicits transcriptional and translational events that on the whole tend to be neuroprotective and neurogenic, fairly specific changes that appear to target the underlying pathological causes of disease in these various mouse models have been noted. These include a possible restoration of brain-derived neurotrophic factor striatal transport in the R6/1 Huntington's mice and an elevation in the levels of amyloid-degrading enzyme neprilysin in the APPswe/PS1ΔE9 Alzheimic mice. An elevation in glial-derived neurotrophic factor coupled to a reduction in dopamine transporter may underlie beneficial effects in mice with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonian symptoms. How all these findings would translate to disease settings in human patients are unclear, but they do provide useful leads for further clinical and paraclinical investigations. © 2005 Elsevier Inc. All rights reserved.
Source Title: Biochemical and Biophysical Research Communications
ISSN: 0006291X
DOI: 10.1016/j.bbrc.2005.05.162
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Jan 30, 2023


checked on Jan 30, 2023

Page view(s)

checked on Jan 26, 2023

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.