Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bbrc.2005.10.059
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dc.titleCdh1-APC/C, cyclin B-Cdc2, and Alzheimer's disease pathology
dc.contributor.authorAulia, S.
dc.contributor.authorTang, B.L.
dc.date.accessioned2011-11-29T05:58:51Z
dc.date.available2011-11-29T05:58:51Z
dc.date.issued2006
dc.identifier.citationAulia, S., Tang, B.L. (2006). Cdh1-APC/C, cyclin B-Cdc2, and Alzheimer's disease pathology. Biochemical and Biophysical Research Communications 339 (1) : 1-6. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bbrc.2005.10.059
dc.identifier.issn0006291X
dc.identifier.issn10902104
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/28736
dc.description.abstractThe anaphase-promoting complex/cyclosome (APC/C) is a key E3 ubiquitin ligase complex that functions in regulating cell cycle transitions in proliferating cells and has, as revealed recently, novel roles in postmitotic neurons. Regulated by its activator Cdh1 (or Hct1), whose level is high in postmitotic neurons, APC/C seems to have multiple functions at different cellular locations, modulating diverse processes such as synaptic development and axonal growth. These processes do not, however, appear to be directly connected to cell cycle regulation. It is now shown that Cdh1-APC/C activity may also have a basic role in suppressing cyclin B levels, thus preventing terminally differentiated neurons from aberrantly re-entering the cell cycle. The result of an aberrant cyclin B-induced S-phase entry, at least for some of these neurons, would be death via apoptosis. Cdh1 thus play an active role in maintaining the terminally differentiated, non-cycling state of postmitotic neurons-a function that could become impaired in Alzheimer's and other neurodegenerative diseases. © 2005 Elsevier Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.bbrc.2005.10.059
dc.sourceScopus
dc.subjectAlzheimer's disease
dc.subjectAnaphase-promoting complex/cyclosome
dc.subjectCdh1
dc.subjectCell cycle
dc.subjectCyclin B
dc.subjectNeuron
dc.typeReview
dc.contributor.departmentBIOCHEMISTRY
dc.description.doi10.1016/j.bbrc.2005.10.059
dc.description.sourcetitleBiochemical and Biophysical Research Communications
dc.description.volume339
dc.description.issue1
dc.description.page1-6
dc.description.codenBBRCA
dc.identifier.isiut000233944500001
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