Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bbrc.2006.09.131
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dc.titleThe reaction of flavonoid metabolites with peroxynitrite
dc.contributor.authorPollard, S.E.
dc.contributor.authorVauzour, D.
dc.contributor.authorVafeiadou, K.
dc.contributor.authorTzounis, X.
dc.contributor.authorSpencer, J.P.E.
dc.contributor.authorKuhnle, G.G.C.
dc.contributor.authorRice-Evans, C.
dc.contributor.authorWhiteman, M.
dc.date.accessioned2011-11-29T05:58:10Z
dc.date.available2011-11-29T05:58:10Z
dc.date.issued2006
dc.identifier.citationPollard, S.E., Vauzour, D., Vafeiadou, K., Tzounis, X., Spencer, J.P.E., Kuhnle, G.G.C., Rice-Evans, C., Whiteman, M. (2006). The reaction of flavonoid metabolites with peroxynitrite. Biochemical and Biophysical Research Communications 350 (4) : 960-968. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bbrc.2006.09.131
dc.identifier.issn0006291X
dc.identifier.issn10902104
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/28675
dc.description.abstractThere is much interest in the bioactivity of in vivo flavonoid metabolites. We report for the first time the hierarchy of reactivity of flavonoid metabolites with peroxynitrite and characterise novel reaction products. O-Methylation of the B-ring catechol containing flavonoids epicatechin and quercetin, and O-glucuronidation of all flavonoids reduced their reactivity with peroxynitrite. The reaction of the flavanones hesperetin and naringenin and their glucuronides resulted in the formation of multiple mono-nitrated and nitrosated products. In contrast, the catechol-containing flavonoids epicatechin and quercetin yielded oxidation products which when trapped with glutathione led to the production of glutathionyl-conjugates. However, the O-methylated metabolites of epicatechin yielded both mono- and di-nitrated products and nitrosated metabolites. The 3′-O-methyl metabolite of quercetin also yielded a nitrosated species, although its counterpart 4′-O-methyl quercetin yielded only oxidation products. Such products may represent novel metabolic products in vivo and may also express cellular activity. © 2006 Elsevier Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.bbrc.2006.09.131
dc.sourceScopus
dc.subject3-Nitrotyrosine
dc.subjectFlavonoid
dc.subjectGlucuronide
dc.subjectMetabolite
dc.subjectO-Methylated
dc.subjectPeroxynitrite
dc.typeArticle
dc.contributor.departmentBIOCHEMISTRY
dc.description.doi10.1016/j.bbrc.2006.09.131
dc.description.sourcetitleBiochemical and Biophysical Research Communications
dc.description.volume350
dc.description.issue4
dc.description.page960-968
dc.description.codenBBRCA
dc.identifier.isiut000241690800024
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