Please use this identifier to cite or link to this item:
Title: The reaction of flavonoid metabolites with peroxynitrite
Authors: Pollard, S.E.
Vauzour, D.
Vafeiadou, K.
Tzounis, X.
Spencer, J.P.E.
Kuhnle, G.G.C.
Rice-Evans, C.
Whiteman, M. 
Keywords: 3-Nitrotyrosine
Issue Date: 2006
Citation: Pollard, S.E., Vauzour, D., Vafeiadou, K., Tzounis, X., Spencer, J.P.E., Kuhnle, G.G.C., Rice-Evans, C., Whiteman, M. (2006). The reaction of flavonoid metabolites with peroxynitrite. Biochemical and Biophysical Research Communications 350 (4) : 960-968. ScholarBank@NUS Repository.
Abstract: There is much interest in the bioactivity of in vivo flavonoid metabolites. We report for the first time the hierarchy of reactivity of flavonoid metabolites with peroxynitrite and characterise novel reaction products. O-Methylation of the B-ring catechol containing flavonoids epicatechin and quercetin, and O-glucuronidation of all flavonoids reduced their reactivity with peroxynitrite. The reaction of the flavanones hesperetin and naringenin and their glucuronides resulted in the formation of multiple mono-nitrated and nitrosated products. In contrast, the catechol-containing flavonoids epicatechin and quercetin yielded oxidation products which when trapped with glutathione led to the production of glutathionyl-conjugates. However, the O-methylated metabolites of epicatechin yielded both mono- and di-nitrated products and nitrosated metabolites. The 3′-O-methyl metabolite of quercetin also yielded a nitrosated species, although its counterpart 4′-O-methyl quercetin yielded only oxidation products. Such products may represent novel metabolic products in vivo and may also express cellular activity. © 2006 Elsevier Inc. All rights reserved.
Source Title: Biochemical and Biophysical Research Communications
ISSN: 0006291X
DOI: 10.1016/j.bbrc.2006.09.131
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.