Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.tcb.2006.07.002
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dc.titleNonvesicular sterol transport: two protein families and a sterol sensor?
dc.contributor.authorYang, H.
dc.date.accessioned2011-11-29T05:57:31Z
dc.date.available2011-11-29T05:57:31Z
dc.date.issued2006
dc.identifier.citationYang, H. (2006). Nonvesicular sterol transport: two protein families and a sterol sensor?. Trends in Cell Biology 16 (9) : 427-432. ScholarBank@NUS Repository. https://doi.org/10.1016/j.tcb.2006.07.002
dc.identifier.issn09628924
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/28626
dc.description.abstractSterols, essential components of eukaryotic membranes, are actively transported between cellular membranes. Although it is known that both vesicular and non-vesicular means are used to move sterols, the molecules and molecular mechanisms involved have yet to be identified. Recent studies point to a key role for oxysterol binding protein (OSBP) and its related proteins (ORPs) in nonvesicular sterol transport. Here, evidence that OSBP and ORPs are bona fide sterol carriers is discussed. In addition, I hypothesize that ATPases associated with various cellular activities regulate the recycling of soluble lipid carriers and that the Niemann Pick C1 protein facilitates the delivery of sterols from endosomal membranes to ORPs and/or the ensuing membrane dissociation of ORPs. © 2006 Elsevier Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.tcb.2006.07.002
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentBIOCHEMISTRY
dc.description.doi10.1016/j.tcb.2006.07.002
dc.description.sourcetitleTrends in Cell Biology
dc.description.volume16
dc.description.issue9
dc.description.page427-432
dc.description.codenTCBIE
dc.identifier.isiut000240886800001
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