Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ydbio.2009.12.005
DC FieldValue
dc.titleC. elegans BED domain transcription factor BED-3 controls lineage-specific cell proliferation during organogenesis
dc.contributor.authorInoue, T.
dc.contributor.authorSternberg, P.W.
dc.date.accessioned2011-11-29T02:59:39Z
dc.date.available2011-11-29T02:59:39Z
dc.date.issued2010
dc.identifier.citationInoue, T., Sternberg, P.W. (2010). C. elegans BED domain transcription factor BED-3 controls lineage-specific cell proliferation during organogenesis. Developmental Biology 338 (2) : 226-236. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ydbio.2009.12.005
dc.identifier.issn00121606
dc.identifier.issn1095564X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/28546
dc.description.abstractThe control of cell division is critical to organogenesis, but how this control is achieved is not fully understood. We found that mutations in bed-3, encoding a BED Zn-finger domain transcription factor, confer a phenotype where a specific set of cell divisions during vulval organogenesis is lost. Unlike general cell cycle regulators in Caenorhabditis elegans, the function of bed-3 is restricted to specific lineages. Transcriptional reporters suggest that bed-3 is expressed in a limited number of cell types including vulval cells whose divisions are affected in bed-3 mutants. A bed-3 mutation also affects the expression pattern of the cdh-3 cadherin gene in the vulva. The phenotype of bed-3 mutants is similar to the phenotype caused by mutations in cog-1 (Nkx6), a component of a gene regulatory network controlling cell type specific gene expression in the vulval lineage. These results suggest that bed-3 is a key component linking the gene regulatory network controlling cell-type specification to control of cell division during vulval organogenesis. © 2009 Elsevier Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.ydbio.2009.12.005
dc.sourceScopus
dc.subjectBED domain
dc.subjectC. elegans
dc.subjectCell cycle regulation
dc.subjectCell division
dc.subjectCell proliferation
dc.subjectGene regulatory network (GRN)
dc.subjectOrganogenesis
dc.subjectTranscription
dc.subjectZinc finger
dc.typeArticle
dc.contributor.departmentBIOCHEMISTRY
dc.description.doi10.1016/j.ydbio.2009.12.005
dc.description.sourcetitleDevelopmental Biology
dc.description.volume338
dc.description.issue2
dc.description.page226-236
dc.description.codenDEBIA
dc.identifier.isiut000274436000011
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