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|Title:||C. elegans BED domain transcription factor BED-3 controls lineage-specific cell proliferation during organogenesis||Authors:||Inoue, T.
Cell cycle regulation
Gene regulatory network (GRN)
|Issue Date:||2010||Citation:||Inoue, T., Sternberg, P.W. (2010). C. elegans BED domain transcription factor BED-3 controls lineage-specific cell proliferation during organogenesis. Developmental Biology 338 (2) : 226-236. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ydbio.2009.12.005||Abstract:||The control of cell division is critical to organogenesis, but how this control is achieved is not fully understood. We found that mutations in bed-3, encoding a BED Zn-finger domain transcription factor, confer a phenotype where a specific set of cell divisions during vulval organogenesis is lost. Unlike general cell cycle regulators in Caenorhabditis elegans, the function of bed-3 is restricted to specific lineages. Transcriptional reporters suggest that bed-3 is expressed in a limited number of cell types including vulval cells whose divisions are affected in bed-3 mutants. A bed-3 mutation also affects the expression pattern of the cdh-3 cadherin gene in the vulva. The phenotype of bed-3 mutants is similar to the phenotype caused by mutations in cog-1 (Nkx6), a component of a gene regulatory network controlling cell type specific gene expression in the vulval lineage. These results suggest that bed-3 is a key component linking the gene regulatory network controlling cell-type specification to control of cell division during vulval organogenesis. © 2009 Elsevier Inc. All rights reserved.||Source Title:||Developmental Biology||URI:||http://scholarbank.nus.edu.sg/handle/10635/28546||ISSN:||00121606
|Appears in Collections:||Staff Publications|
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