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Title: Running and Adult neurogenesis: Does septohippocampal sonic hedgehog play a role?
Authors: HO NEW FEI
Keywords: adult neurogenesis, running, hippocampus, sonic hedgehog, septohippocampal and progenitor proliferation
Issue Date: 8-Jun-2009
Citation: HO NEW FEI (2009-06-08). Running and Adult neurogenesis: Does septohippocampal sonic hedgehog play a role?. ScholarBank@NUS Repository.
Abstract: This study aims to elucidate mechanisms of exercise-mediated adult rodent neurogenesis. Running is associated with hippocampal theta rhythm, which is critically dependent on medial septum and diagonal band of Broca (MSDB) afferents. Specific lesions showed that septohippocampal cholinergic cells were not responsible for running-induced neurogenesis (assessed with bromodeoxyuridine). mRNA and protein expression of a putative candidate sonic hedgehog (Shh) were observed in the MSDB. Shh was co-expressed with MSDB GABAergic perikarya, with presumptive varicosities in the dentate gyrus in apposition with stem cell markers. Disruption of axonal transport by colchicine and retrograde-labelling suggested that Shh might be delivered from MSDB to hippocampus, largely by GABAergic projections. Pharmacological inhibition of Shh signalling suppressed both running-induced progenitor proliferation and Gli1 (a metric of Shh signalling) mRNA and protein expression.It is proposed that running evokes theta and concomitant release of Shh mitogen from septohippocampal GABAergic neurons, resulting in progenitor proliferation.
Appears in Collections:Ph.D Theses (Open)

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