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https://scholarbank.nus.edu.sg/handle/10635/28325
DC Field | Value | |
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dc.title | Role of Abberant Proteolysis in the Pathogenesis of APL | |
dc.contributor.author | NG PING PING ANGELA | |
dc.date.accessioned | 2011-11-08T18:04:16Z | |
dc.date.available | 2011-11-08T18:04:16Z | |
dc.date.issued | 2009-05-26 | |
dc.identifier.citation | NG PING PING ANGELA (2009-05-26). Role of Abberant Proteolysis in the Pathogenesis of APL. ScholarBank@NUS Repository. | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/28325 | |
dc.description.abstract | Acute promyelocytic leukemia (APL), a subtype of acute myeloid leukemia (AML), is caused by PML-RARN1, a fusion protein resulting from chromosomal translocation involving the promyelocytic leukemia (PML) and the retinoic acid receptor N1 (RARN1) genes. PML-RARN1 promotes misfolding of nuclear hormone receptor corepressor (N-CoR) and that accumulation of misfolded N-CoR in the ER induces endoplasmic reticulum (ER) stress and activates unfolded protein response (UPR). Although accumulation of misfolded proteins is known to trigger UPR-induced cytotoxic cell death in several neurodegenerative disorders, APL cells are notably resistant to UPR-induced apoptosis. This project was initiated with the goals to investigate how N-CoR misfolding supports the survival and growth of APL cells, and to screen potential therapeutic agents that could induce growth arrest through targeting the misfolded N-CoR-induced survival pathways in APL. | |
dc.language.iso | en | |
dc.subject | Unfolded Protein Response, Autophagy, ER stress, Acute Promyelocytic Leukemia, Apoptosis, N-CoR | |
dc.type | Thesis | |
dc.contributor.department | NUS GRAD SCH FOR INTEGRATIVE SCI & ENGG | |
dc.contributor.supervisor | ITO, YOSHIAKI | |
dc.description.degree | Ph.D | |
dc.description.degreeconferred | DOCTOR OF PHILOSOPHY | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Ph.D Theses (Open) |
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File | Description | Size | Format | Access Settings | Version | |
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Phd Thesis - Ng Ping Ping Angela.pdf | 10.75 MB | Adobe PDF | OPEN | None | View/Download |
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