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Title: Cytomegalovirus infections in Solid Organ transplant recipients
Keywords: cytomegalovirus, solid organ transplant recipients, resistance
Issue Date: 27-Dec-2007
Citation: YEO CHAO CHUANG, ADRIAN (2007-12-27). Cytomegalovirus infections in Solid Organ transplant recipients. ScholarBank@NUS Repository.
Abstract: Published data on the impact of cytomegalovirus (CMV) infection and disease in Singapore is limited. Laboratory investigations of CMV ganciclovir resistance revealed its presence in 25% of renal and 40% of liver transplant recipients. We improved on genotypic screening methods by developing several rapid PCR-based assays for detection of specific mutations in CMV which could be utilized directly on clinical samples. The association between CMV infection and disease on long-term outcome after kidney transplantation is still unsettled. Logistic regression analyses of clinical data from our prospective study of 119 consecutive renal transplant subjects showed a significant correlation between allograft dysfunction at one year post-transplant and presence of CMV DNAemia at five months post-transplant (P< 0.01; OR 2.864, 95% CI 1.046-7.839). We also observed that presence of IgG specific anti-endothelial cell antibody (AECA) activity was significantly associated with CMV DNAemia (P < 0.01).
Appears in Collections:Ph.D Theses (Open)

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