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Title: Capillary and microchip electrophoresis for the analysis of small biomolecules
Keywords: microchip, small biomolecules, ionic liquid, aptamers
Issue Date: 29-Apr-2009
Citation: TAY TENG TENG, ELAINE (2009-04-29). Capillary and microchip electrophoresis for the analysis of small biomolecules. ScholarBank@NUS Repository.
Abstract: In this work, capillary electrophoresis and its miniaturized counterpart, microchip capillary electrophoresis, were used in the study of various small biomolecules including adenosine, amino acids and polyamines. Capillary electrophoresis was first utilized in the evaluation of the extraction efficiency of a unique target specific ionic liquid-aptamer based extractant for adenosine. It was observed that such an extractant had some selectivity for adenosine over other structurally similar compounds. To increase the throughput and universal application of capillary electrophoresis study of small biomolecules, a microchip was designed for a novel conductivity detector, the floating resistivity detector, FRD. The various parameters of the detection window on the floating resistivity detector microchip were optimized stepwise. Consequently, floating resistivity detector and the optimized microchip were used to analyze metal ions and the small biomolecules with good sensitivity and repeatability.
Appears in Collections:Master's Theses (Open)

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