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|Title:||The regulation of annexin-A1's expression and function(s) by 17-Beta-Estradiol in MCF7 Breast cancer cells||Authors:||ANG ZHAO FENG, EMILY||Keywords:||Annexin-A1, 17-beta-estradiol, MCF7, breast cancer, MAPK/ERK||Issue Date:||19-Feb-2008||Citation:||ANG ZHAO FENG, EMILY (2008-02-19). The regulation of annexin-A1's expression and function(s) by 17-Beta-Estradiol in MCF7 Breast cancer cells. ScholarBank@NUS Repository.||Abstract:||Both estrogen and Annexin-A1 (Anx-A1) have been implicated in breast cancer and are also able to regulate the mitogen-activated protein kinase/ extracellular signal-regulated kinase (MAPK/ERK) pathway. We hence hypothesize that estrogen (17-beta-estradiol/E2) may induce the expression of Anx-A1 for the regulation of cell proliferation via the MAPK signaling pathway. We show that prolonged exposure of cells to high physiological levels of E2 led to an up-regulation of Anx-A1 expression and a corresponding inhibition of cell proliferation. In addition, Anx-A1 had direct anti-proliferative effects on cells, possibly via a constitutive over-activation of ERK. Finally, the anti-proliferative role of Anx-A1 was directly responsible for the reduced proliferation rates observed when cells were exposed to high E2 concentrations for an extended time period. We thus believe that Anx-A1 may act as a tumor suppressor in cells and that its expression could be increased, when needed, to put a brake on uncontrolled cellular proliferation.||URI:||http://scholarbank.nus.edu.sg/handle/10635/28225|
|Appears in Collections:||Master's Theses (Open)|
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