Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/28216
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dc.titleControlled release alginate-based microparticulate systems for drug delivery and chemoembolization
dc.contributor.authorLIU XIAOHUA
dc.date.accessioned2011-11-08T18:02:05Z
dc.date.available2011-11-08T18:02:05Z
dc.date.issued2008-02-13
dc.identifier.citationLIU XIAOHUA (2008-02-13). Controlled release alginate-based microparticulate systems for drug delivery and chemoembolization. ScholarBank@NUS Repository.
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/28216
dc.description.abstractAlginate as particulate carriers has the limitation of rapid drug release due to the porous alginate matrix. The main objective of this study was to develop controlled release alginate microspheres. A novel liquid phase coating (LPC) technique was developed to produce polymer-reinforced alginate microspheres. Composite microspheres prepared by a multiple emulsion technique were also developed. Optimized formulations with good physicochemical properties were successfully produced and studied. The coated microspheres prepared with LPC showed markedly reduced drug release compared to the uncoated control. The release mechanism and rate were affected by the type of polymethyl methacrylate, core:coat ratio and dissolution media. Drug release rate of poly (lactic-co-glycolic) acid (PLGA)-alginate microspheres was also successfully controlled by changing PLGA content in the alginate microspheres. Norcantharidin-loaded PLGA-alginate microspheres markedly increased the survival time of rats with transplanted hepatoma showing the potential of the microspheres as chemoembolization agent in the treatment of liver cancer.
dc.language.isoen
dc.subjectalginate; microspheres; controlled-release; liquid-phase-coating; norcantharidin; chemoembolization
dc.typeThesis
dc.contributor.departmentPHARMACY
dc.contributor.supervisorCHAN LAI WAH
dc.contributor.supervisorHENG WAN SIA, PAUL
dc.description.degreePh.D
dc.description.degreeconferredDOCTOR OF PHILOSOPHY
dc.identifier.isiutNOT_IN_WOS
Appears in Collections:Ph.D Theses (Open)

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