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Title: Probing the Functions of Transcription Regulators in Embryonic Stem Cells
Keywords: Embryonic stem cell, gene regulation, epigenetic regulation, transcriptional network, self-renewal, pluripotency
Issue Date: 22-Feb-2008
Citation: LOH YUIN HAN (2008-02-22). Probing the Functions of Transcription Regulators in Embryonic Stem Cells. ScholarBank@NUS Repository.
Abstract: Embryonic stem (ES) cells are pluripotent cells with the ability to self-renew indefinitely. These unique properties of ES cells are controlled by genetic and epigenetic factors. The aim of our study is to identify, characterize and understand the role of transcriptional regulators and chromatin-modifying enzymes in regulating gene expression programs in ES cells. Specifically, we want to understand 1) the relationships between Oct4, Sox2 and Nanog, whether they function in distinct pathways or operate inter-dependently 2) the regulation of downstream genomic targets by the key factors, which will be instrumental in delineating their specific biological functions in governing ES cell pluripotency 3) the functional relevance of the downstream targets and the identification of downstream effectors which may have novel roles in propagating the effects of the core network 4) the mechanisms whereby the core transcription factors can modulate the open chromatin architecture of the pluripotent ES cells .
Appears in Collections:Ph.D Theses (Open)

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