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Title: Development and Evaluation of Sucrose Ester Stabilized Oleanolic Acid Nanosuspensions
Authors: LI WENJI
Keywords: oleanolic acid, nanosuspension, sucrose ester, bioavailability, saturation solubility, dissolution rate
Issue Date: 30-Mar-2011
Citation: LI WENJI (2011-03-30). Development and Evaluation of Sucrose Ester Stabilized Oleanolic Acid Nanosuspensions. ScholarBank@NUS Repository.
Abstract: The aim of this study was to develop new sucrose ester stabilized oleanolic acid nanosuspension to enhance its delivery by increasing the saturation solubility, bioefficacy and bioavailability. O/W emulsion and organic solvent evaporation method and wet ball milling method were used to develop the nanosuspensions. Both methods yielded nano ranged particles and enhanced saturation solubility. However, nanosuspension produced by solvent evaporation method was physically and chemically more stable than by wet ball milling method. The dissolution rate and cytotoxicity were both increased by either of the two methods. Preliminary studies indicated that cellular uptake of SEOA nanosuspension by A549 cells was temperature-, concentration- and time-dependent. The oral bioavailability also gained a big increase. Two methods were both successfully in preparing SEOA nanosuspension, providing a novel way to enhance saturation solubility, in vitro dissolution rate, bioefficacy and in vivo bioavailability of free oleanolic acid and/or other potentially useful hydrophobic drugs.
Appears in Collections:Ph.D Theses (Open)

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