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https://scholarbank.nus.edu.sg/handle/10635/27843
DC Field | Value | |
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dc.title | Regulation of the TRIP-BR1 proto-oncoprotein - a potential therapeutic target for human cutaneous and intracavitory proliferative lesions | |
dc.contributor.author | ZANG ZHIJIANG | |
dc.date.accessioned | 2011-10-18T18:02:05Z | |
dc.date.available | 2011-10-18T18:02:05Z | |
dc.date.issued | 2008-04-09 | |
dc.identifier.citation | ZANG ZHIJIANG (2008-04-09). Regulation of the TRIP-BR1 proto-oncoprotein - a potential therapeutic target for human cutaneous and intracavitory proliferative lesions. ScholarBank@NUS Repository. | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/27843 | |
dc.description.abstract | TRIP-Br proteins are transcriptional regulators functioning at E2F1 promoter to integrate signals provided by PHD-bromodomain-containing proteins. Herein we demonstrated the synthetic decoy peptides competing with TRIP-Br1/2 for binding to PHD-bromodomain proteins elicited an anti-proliferative effect in representative human nasopharyngeal, cervical and melanoma cancer cells in vitro and in vivo. Serine/threonine protein phosphatase 2A (PP2A) BN1 was identified as a TRIP-Br-1 interactor. TRIP-Br1 is serine-phosphorylated. Inhibition of PP2A by okadaic acid or PP2A-C siRNA increased serine phosphorylated TRIP-Br1 and decreased total TRIP-Br1 protein level. Overexpression of the PP2A-C increased the total TRIP-Br1 protein and TRIP-Br1 co-activated of E2F1/DP1 transcription. Our data suggest antagonizing the integrator function of TRIP-Br may represent important chemotherapeutic drug target for superficial cutaneous and intracavitary hyperproliferative lesions and TRIP-Br1 protein level is positively regulates by PP2A. Uncovering the mechanism of TRIP-Br protein regulation may facilitate the application of therapeutic strategies targeting TRIP-Br proteins in human diseases. | |
dc.language.iso | en | |
dc.subject | TRIP-Br1, PP2A, protein phosphatase, E2F, Neoplasm, chick embryo chorioallantoic membrane | |
dc.type | Thesis | |
dc.contributor.department | MEDICINE | |
dc.contributor.supervisor | HSU, STEPHEN I-HONG | |
dc.contributor.supervisor | SALTO-TELLEZ, MANUEL | |
dc.description.degree | Ph.D | |
dc.description.degreeconferred | DOCTOR OF PHILOSOPHY | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Ph.D Theses (Open) |
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File | Description | Size | Format | Access Settings | Version | |
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PhD thesis (Zhijiang Zang 2007).pdf | 2.67 MB | Adobe PDF | OPEN | None | View/Download |
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