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Title: Characterisation of CD137 as a neoantigen on cancer cells
Keywords: CD137, cancer, neoantigen
Issue Date: 27-Mar-2008
Citation: THUM HUEI YEE, ELAINE (2008-03-27). Characterisation of CD137 as a neoantigen on cancer cells. ScholarBank@NUS Repository.
Abstract: CD137 is a co-stimulatory receptor found on activated T lymphocytes and certain cancer cells. In particular, CD137 was detected on B cells in 14 out of 14 cases of chronic lymphocytic leukaemia analysed, but not in healthy B cell samples. Thus, this study aims to characterize the potential role of CD137 as a cancer neoantigen. Using cell lines which overexpress CD137, it was found that CD137 does not protect cancer cells against cell death mediated by lymphokine activated killer cells and chemotherapeutic drugs. Also, CD137-expressing cells do not enhance monocyte adhesion, a process which may increase the number of tumour associated macrophages. These in vitro data suggest that CD137 expression does not confer a survival advantage upon cancer cells. Finally, to understand how soluble CD137 might disrupt CD137-mediated signaling, this study also aims to determine if soluble CD137 associates with membrane-bound CD137. Our results, however, suggest that this is unlikely to be the case.
Appears in Collections:Master's Theses (Open)

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