Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bbrc.2005.09.059
DC FieldValue
dc.titleOltipraz-induced phase 2 enzyme response conserved in cells lacking mitochondrial DNA
dc.contributor.authorChua, Y.L.
dc.contributor.authorZhang, D.
dc.contributor.authorWhiteman, M.
dc.contributor.authorArmstrong, J.S.
dc.contributor.authorBoelsterli, U.
dc.contributor.authorMoore, P.K.
dc.date.accessioned2011-09-29T06:42:57Z
dc.date.available2011-09-29T06:42:57Z
dc.date.issued2005
dc.identifier.citationChua, Y.L., Zhang, D., Whiteman, M., Armstrong, J.S., Boelsterli, U., Moore, P.K. (2005). Oltipraz-induced phase 2 enzyme response conserved in cells lacking mitochondrial DNA. Biochemical and Biophysical Research Communications 337 (1) : 375-381. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bbrc.2005.09.059
dc.identifier.issn0006291X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/27412
dc.description.abstractOltipraz, a member of a class of 1,2-dithiolethiones, is a potent phase 2 enzyme inducing agent used as a cancer chemopreventive. In this study, we investigated regulation of the phase 2 enzyme response and protection against endogenous oxidative stress in lymphoblastic leukemic parental CEM cells and cells lacking mitochondrial DNA (mtDNA) (ρ0) by oltipraz. Glutathione (GSH) levels (total and mitochondrial) and glutathione S-transferase (GST) activity were significantly increased after pretreatment with oltipraz in both parental (ρ+) and ρ0 cells, and both cell lines were resistant to mitochondrial oxidation, loss of mitochondrial membrane potential, and cell death in response to the GSH depleting agent diethylmaleate. These results show that the phase 2 enzyme response, by enhancing GSH-dependent systems involved in xenobiotic metabolism, blocks endogenous oxidative stress and cell death, and that this response is intact in cells lacking mtDNA. © 2005 Elsevier Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.bbrc.2005.09.059
dc.sourceScopus
dc.subjectρ0
dc.subjectGlutathione
dc.subjectGlutathione S-transferase
dc.subjectMitochondrial permeability transition
dc.subjectmtDNA
dc.subjectOltipraz
dc.subjectReactive oxygen species
dc.typeArticle
dc.contributor.departmentBIOCHEMISTRY
dc.contributor.departmentPHARMACOLOGY
dc.description.doi10.1016/j.bbrc.2005.09.059
dc.description.sourcetitleBiochemical and Biophysical Research Communications
dc.description.volume337
dc.description.issue1
dc.description.page375-381
dc.identifier.isiut000232584000056
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

12
checked on Jul 2, 2020

WEB OF SCIENCETM
Citations

10
checked on Jul 2, 2020

Page view(s)

174
checked on Jun 30, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.