Please use this identifier to cite or link to this item:
Title: Meta-analysis of genetic polymorphisms and gastric cancer risk: Variability in associations according to race
Authors: Loh, M.
Koh, K.X.
Soong, R. 
Yeo, B.H.
Song, C.M.
Chia, K.S. 
Zhu, F. 
Yeoh, K.G. 
Hill, J.
Iacopetta, B.
Keywords: Gastric cancer
Genetic variability
Issue Date: 2009
Citation: Loh, M., Koh, K.X., Soong, R., Yeo, B.H., Song, C.M., Chia, K.S., Zhu, F., Yeoh, K.G., Hill, J., Iacopetta, B. (2009). Meta-analysis of genetic polymorphisms and gastric cancer risk: Variability in associations according to race. European Journal of Cancer 45 (14) : 2562-2568. ScholarBank@NUS Repository.
Abstract: The goal of this study was to consolidate information on genetic risk factors for gastric cancer. An additional aim was to investigate the influence of race on these genetic risk associations. Relevant studies were identified from PubMed and references of retrieved articles. Meta-analysis techniques were used to summarise associations between genetic polymorphisms and gastric cancer. A total of 203 relevant studies were identified, assessing 225 polymorphisms across 95 genes. Subgroup analysis indicated that Chinese, Japanese and Korean data were consistent and could be pooled. However, 6 of 13 polymorphisms (ACE I/D, CCND1 870G > A, CDH1 -160C > A, IL1B -511C > T, IL4 -590C > T, IL10 -592A > C) displayed conflicting effects between Asian and Caucasian populations, three of which (ACE I/D, CCND1 870G > A, IL1B -511C > T) had significantly different odds ratios between the two racial groups. In total, 37 polymorphisms across 27 genes were found to be significantly associated with gastric cancer in Asians, and 12 polymorphisms across 11 genes in Caucasians. Consolidated panels of polymorphisms associated with gastric cancer risk were identified in Asians and Caucasians. The results caution against the assumption that genetic risk factors are consistent between races. © 2009 Elsevier Ltd. All rights reserved.
Source Title: European Journal of Cancer
ISSN: 09598049
DOI: 10.1016/j.ejca.2009.03.017
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Jan 28, 2022


checked on Jan 28, 2022

Page view(s)

checked on Jan 27, 2022

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.