Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.neuint.2006.05.008
DC FieldValue
dc.titleSpastin in the human and mouse central nervous system with special reference to its expression in the hippocampus of mouse pilocarpine model of status epilepticus and temporal lobe epilepsy
dc.contributor.authorMa, D.L.
dc.contributor.authorChia, S.C.
dc.contributor.authorTang, Y.C.
dc.contributor.authorChang, M.L.J.
dc.contributor.authorTang, F.R.
dc.contributor.authorProbst, A.
dc.contributor.authorBurgunder, J.-M.
dc.date.accessioned2011-09-27T05:45:01Z
dc.date.available2011-09-27T05:45:01Z
dc.date.issued2006
dc.identifier.citationMa, D.L., Chia, S.C., Tang, Y.C., Chang, M.L.J., Tang, F.R., Probst, A., Burgunder, J.-M. (2006). Spastin in the human and mouse central nervous system with special reference to its expression in the hippocampus of mouse pilocarpine model of status epilepticus and temporal lobe epilepsy. Neurochemistry International 49 (7) : 651-664. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neuint.2006.05.008
dc.identifier.issn01970186
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/27127
dc.description.abstractIn the present in situ hybridization and immunocytochemical studies in the mouse central nervous system (CNS), a strong expression of spastin mRNA and protein was found in Purkinje cells and dentate nucleus in the cerebellum, in hippocampal principal cells and hilar neurons, in amygdala, substantia nigra, striatum, in the motor nuclei of the cranial nerves and in different layers of the cerebral cortex except piriform and entorhinal cortices where only neurons in layer II were strongly stained. Spastin protein and mRNA were weakly expressed in most of the thalamic nuclei. In selected human brain regions such as the cerebral cortex, cerebellum, hippocampus, amygdala, substania nigra and striatum, similar results were obtained. Electron microscopy showed spastin immunopositive staining in the cytoplasma, dendrites, axon terminals and nucleus. In the mouse pilocarpine model of status epilepticus and subsequent temporal lobe epilepsy, spastin expression disappeared in hilar neurons as early as at 2 h during pilocarpine induced status epilepticus, and never recovered. At 7 days and 2 months after pilocarpine induced status epilepticus, spastin expression was down-regulated in granule cells in the dentate gyrus, but induced expression was found in reactive astrocytes. The demonstration of widespread distribution of spastin in functionally different brain regions in the present study may provide neuroanatomical basis to explain why different neurological, psychological disorders and cognitive impairment occur in patients with spastin mutation. Down-regulation or loss of spastin expression in hilar neurons may be related to their degeneration and may therefore initiate epileptogenetic events, leading to temporal lobe epilepsy. © 2006 Elsevier Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.neuint.2006.05.008
dc.sourceScopus
dc.subjectCentral nervous system
dc.subjectDistribution
dc.subjectEpilepsy
dc.subjectHippocampus
dc.subjectHuman
dc.subjectMouse
dc.subjectSpastin
dc.typeArticle
dc.contributor.departmentMEDICINE
dc.contributor.departmentANATOMY
dc.description.doi10.1016/j.neuint.2006.05.008
dc.description.sourcetitleNeurochemistry International
dc.description.volume49
dc.description.issue7
dc.description.page651-664
dc.identifier.isiut000242266700003
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

11
checked on Oct 22, 2020

WEB OF SCIENCETM
Citations

11
checked on Oct 22, 2020

Page view(s)

195
checked on Oct 6, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.