Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jocn.2007.01.013
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dc.titleElectroencephalographic changes and seizures in familial hemiplegic migraine patients with the CACNA1A gene S218L mutation
dc.contributor.authorChan, Y.-C.
dc.contributor.authorWilder-Smith, E.
dc.contributor.authorSharma, V.
dc.contributor.authorOng, B.K.C.
dc.contributor.authorBurgunder, J.-M.
dc.contributor.authorChew, S.-E.
dc.contributor.authorLam-Mok-Sing, K.M.J.
dc.date.accessioned2011-09-27T05:44:41Z
dc.date.available2011-09-27T05:44:41Z
dc.date.issued2008
dc.identifier.citationChan, Y.-C., Wilder-Smith, E., Sharma, V., Ong, B.K.C., Burgunder, J.-M., Chew, S.-E., Lam-Mok-Sing, K.M.J. (2008). Electroencephalographic changes and seizures in familial hemiplegic migraine patients with the CACNA1A gene S218L mutation. Journal of Clinical Neuroscience 15 (8) : 891-894. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jocn.2007.01.013
dc.identifier.issn09675868
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/27096
dc.description.abstractThe S218L CACNA1A mutation has been previously described in two families with familial hemiplegic migraine. We present three siblings with the mutation with the novel association of childhood seizures, and highlight the dynamic changes seen on electroencephalography during hemiplegic migraine attacks. Depressed activity contralateral to the hemiparesis was seen on electroencephalography during acute hemiplegic migraine attacks, which may be due to changes to calcium channels caused by the S218L mutation. Both parents were asymptomatic and did not carry the S218L mutation in their blood. This suggests the presence of mosaicism in the transmitting parent. © 2007 Elsevier Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.jocn.2007.01.013
dc.sourceScopus
dc.subjectCACNA1A gene
dc.subjectCortical spreading depression
dc.subjectElectroencephalography
dc.subjectFamilial hemiplegic migraine
dc.subjectGermline mosaicism
dc.subjectS218L
dc.subjectSeizure
dc.typeArticle
dc.contributor.departmentMEDICINE
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.1016/j.jocn.2007.01.013
dc.description.sourcetitleJournal of Clinical Neuroscience
dc.description.volume15
dc.description.issue8
dc.description.page891-894
dc.identifier.isiut000257868600008
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