Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.leukres.2006.02.026
| Title: | Molecular response of leukemia HL-60 cells to genistein treatment, a proteomics study | Authors: | Zhang, D. Koay, E.S.-C. Tai, Y.-C. Wong, C.-H.S. Chen, C.-S. Tai, L.-K. |
Keywords: | Cell cycle arrest Genistein Leukemia HL-60 Proteomics Tyrosine kinase |
Issue Date: | 2007 | Citation: | Zhang, D., Koay, E.S.-C., Tai, Y.-C., Wong, C.-H.S., Chen, C.-S., Tai, L.-K. (2007). Molecular response of leukemia HL-60 cells to genistein treatment, a proteomics study. Leukemia Research 31 (1) : 75-82. ScholarBank@NUS Repository. https://doi.org/10.1016/j.leukres.2006.02.026 | Abstract: | Genistein (GEN) is a natural protein tyrosine kinase inhibitor. We analyzed the molecular response of HL-60 cells to GEN treatment by gel-based proteomics approach. Fourteen differentially expressed proteins which are functionally involved in metabolism, cell signaling, RNA processing, cell proliferation and motility, and chaperones were identified. Both the dose- and time-dependent up-regulation of Hsp70 protein 8 and heterogeneous nuclear ribonucleoprotein (hnRNP) H1, and the down-regulation of Rab14, hnRNP C and stathmin-1 by GEN were verified by immunoblot analysis. Our novel findings provide insightful clues to the potential therapeutic targets for leukemia treatment in diverse tyrosine kinase-dependent cellular pathways. © 2006 Elsevier Ltd. All rights reserved. | Source Title: | Leukemia Research | URI: | http://scholarbank.nus.edu.sg/handle/10635/27036 | ISSN: | 01452126 | DOI: | 10.1016/j.leukres.2006.02.026 |
| Appears in Collections: | Staff Publications |
Show full item record
Files in This Item:
There are no files associated with this item.
SCOPUSTM
Citations
21
checked on Sep 14, 2020
WEB OF SCIENCETM
Citations
13
checked on Sep 14, 2020
Page view(s)
228
checked on Sep 22, 2020
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.