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Title: Molecular response of leukemia HL-60 cells to genistein treatment, a proteomics study
Authors: Zhang, D. 
Koay, E.S.-C. 
Tai, Y.-C. 
Wong, C.-H.S. 
Chen, C.-S. 
Tai, L.-K. 
Keywords: Cell cycle arrest
Leukemia HL-60
Tyrosine kinase
Issue Date: 2007
Citation: Zhang, D., Koay, E.S.-C., Tai, Y.-C., Wong, C.-H.S., Chen, C.-S., Tai, L.-K. (2007). Molecular response of leukemia HL-60 cells to genistein treatment, a proteomics study. Leukemia Research 31 (1) : 75-82. ScholarBank@NUS Repository.
Abstract: Genistein (GEN) is a natural protein tyrosine kinase inhibitor. We analyzed the molecular response of HL-60 cells to GEN treatment by gel-based proteomics approach. Fourteen differentially expressed proteins which are functionally involved in metabolism, cell signaling, RNA processing, cell proliferation and motility, and chaperones were identified. Both the dose- and time-dependent up-regulation of Hsp70 protein 8 and heterogeneous nuclear ribonucleoprotein (hnRNP) H1, and the down-regulation of Rab14, hnRNP C and stathmin-1 by GEN were verified by immunoblot analysis. Our novel findings provide insightful clues to the potential therapeutic targets for leukemia treatment in diverse tyrosine kinase-dependent cellular pathways. © 2006 Elsevier Ltd. All rights reserved.
Source Title: Leukemia Research
ISSN: 01452126
DOI: 10.1016/j.leukres.2006.02.026
Appears in Collections:Staff Publications

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