Please use this identifier to cite or link to this item:
|Title:||RUNX3 Attenuates β-Catenin/T Cell Factors in Intestinal Tumorigenesis||Authors:||Ito, K.
|Issue Date:||2008||Citation:||Ito, K., Lim, A.C.-B., Motoda, L., Osato, M., Chuang, L.S.H., Lee, C.W.L., Voon, D.C.-C., Ito, Y., Salto-Tellez, M., Koo, J.K.W., Wang, H., Fukamachi, H. (2008). RUNX3 Attenuates β-Catenin/T Cell Factors in Intestinal Tumorigenesis. Cancer Cell 14 (3) : 226-237. ScholarBank@NUS Repository.||Abstract:||In intestinal epithelial cells, inactivation of APC, a key regulator of the Wnt pathway, activates β-catenin to initiate tumorigenesis. However, other alterations may be involved in intestinal tumorigenesis. Here we found that RUNX3, a gastric tumor suppressor, forms a ternary complex with β-catenin/TCF4 and attenuates Wnt signaling activity. A significant fraction of human sporadic colorectal adenomas and Runx3+/- mouse intestinal adenomas showed inactivation of RUNX3 without apparent β-catenin accumulation, indicating that RUNX3 inactivation independently induces intestinal adenomas. In human colon cancers, RUNX3 is frequently inactivated with concomitant β-catenin accumulation, suggesting that adenomas induced by inactivation of RUNX3 may progress to malignancy. Taken together, these data demonstrate that RUNX3 functions as a tumor suppressor by attenuating Wnt signaling. © 2008 Elsevier Inc. All rights reserved.||Source Title:||Cancer Cell||URI:||http://scholarbank.nus.edu.sg/handle/10635/26979||ISSN:||15356108|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.