Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ejpain.2008.09.015
DC FieldValue
dc.titleActivating endogenous visceral pain modulation: A comparison of heterotopic stimulation methods in healthy controls
dc.contributor.authorWilder-Smith, C.H.
dc.contributor.authorSong, G.
dc.contributor.authorYeoh, K.G.
dc.contributor.authorHo, K.Y.
dc.date.accessioned2011-09-27T05:16:12Z
dc.date.available2011-09-27T05:16:12Z
dc.date.issued2009
dc.identifier.citationWilder-Smith, C.H., Song, G., Yeoh, K.G., Ho, K.Y. (2009). Activating endogenous visceral pain modulation: A comparison of heterotopic stimulation methods in healthy controls. European Journal of Pain 13 (8) : 836-842. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ejpain.2008.09.015
dc.identifier.issn10903801
dc.identifier.issn15322149
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/26841
dc.description.abstractAll sensory input underlies modulation by endogenous central nervous system pathways. Dysfunctional endogenous pain modulation has been demonstrated in central sensitization and in several pain syndromes, including Irritable Bowel Syndrome (IBS) Activation of endogenous visceral pain modulation by heterotopic stimulation was compared using different methods. Rectal electrical or distension pain alone or with simultaneous (i.e. heterotopic) noxious hand or foot cold stimulation were investigated in randomized sequence in 14 male and 1 female healthy subjects. Mean pain intensities on a visual analogue scale of 0-100 (95% CI) during tonic rectal electrical and distension stimulation alone were 64 (52-76) and 55 (39-71), respectively. Rectal distension pain decreased by 36% (18-55) with simultaneous hand and by 45% (24-66) with simultaneous foot cold pain. Rectal electrical pain decreased by 45% (29-61) during hand and by 46% (28-64) during foot cold pain. Facilitation, i.e. increased rectal pain during heterotopic stimulation was observed in only 1 of 60 stimulation runs. Potent and consistent activation of endogenous visceral pain inhibition was achieved with heterotopic cold pain limb stimulation. Somato-visceral convergence did not affect the effectiveness of induction of endogenous visceral pain inhibition in healthy subjects, as hand and foot heterotopic stimulation resulted in similar pain inhibition. Pain facilitation, as shown earlier in IBS patients, was not evident in healthy controls. © 2008 European Federation of Chapters of the International Association for the Study of Pain.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.ejpain.2008.09.015
dc.sourceScopus
dc.subjectDiffuse noxious inhibitory controls DNIC
dc.subjectEndogenous pain modulation
dc.subjectIrritable Bowel Syndrome
dc.subjectPain inhibition
dc.subjectVisceral pain
dc.typeArticle
dc.contributor.departmentMEDICINE
dc.description.doi10.1016/j.ejpain.2008.09.015
dc.description.sourcetitleEuropean Journal of Pain
dc.description.volume13
dc.description.issue8
dc.description.page836-842
dc.identifier.isiut000269901300008
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

10
checked on Jul 16, 2019

WEB OF SCIENCETM
Citations

11
checked on Jul 16, 2019

Page view(s)

258
checked on Jul 5, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.