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|Title:||Islet autoimmunity status in Asians with young-onset diabetes (12-40 years): Association with clinical characteristics, beta cell function and cardio-metabolic risk factors||Authors:||Thai, A.C.
|Keywords:||Beta cell function
|Issue Date:||2008||Citation:||Thai, A.C., Mohan, V., Khalid, B.A.K., Cockram, C.S., Pan, C.Y., Zimmet, P., Yeo, J.P. (2008). Islet autoimmunity status in Asians with young-onset diabetes (12-40 years): Association with clinical characteristics, beta cell function and cardio-metabolic risk factors. Diabetes Research and Clinical Practice 80 (2) : 224-230. ScholarBank@NUS Repository. https://doi.org/10.1016/j.diabres.2007.12.003||Abstract:||In this paper, the islet autoimmunity status and relation to clinical characteristics, beta cell function and cardio-metabolic risk factors in young-onset Asian diabetic patients are evaluated at baseline. The study population consisted of 912 patients (from China, India, Malaysia and Singapore) with age 12-40 years and diabetes duration <12 months. Autoantibodies to glutamic acid decarboxylase (GADA) and tyrosine phosphatase (IA-2A), beta cell function and cardio-metabolic risk parameters were assessed. Among our young patient cohort, 105 (11.5%) patients were GADA and/or IA-2A positives (Ab +ve). Ab +ve patients were younger, leaner, had more severe hyperglycaemia and lower beta cell function. The frequency of metabolic syndrome was significantly lower in Ab +ve patients (27%) compared to Ab -ve patients (54%). However, a substantial proportion of patients in both groups of patients had atherogenic dyslipidaemia, hypertension and albuminuria (micro or macro). In our study cohort, only one in 10 Asian youth with new-onset diabetes had evidence of islet autoimmunity. At least 60% of Ab +ve and 50% of Ab -ve patients demonstrated classical features of type 1 and type 2 diabetes respectively. Regardless of autoimmunity status, the cardio-metabolic risk factors, in particular atherogenic dyslipidaemia, hypertension and albuminuria were common in our patients with young-onset diabetes. © 2007 Elsevier Ireland Ltd. All rights reserved.||Source Title:||Diabetes Research and Clinical Practice||URI:||http://scholarbank.nus.edu.sg/handle/10635/26725||ISSN:||01688227||DOI:||10.1016/j.diabres.2007.12.003|
|Appears in Collections:||Staff Publications|
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