Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.mehy.2006.03.014
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dc.titleWhere has all the botox gone? (How) will we ever learn... Using monoclonal antibodies to track botulinum toxin
dc.contributor.authorLim, E.C.-H.
dc.contributor.authorOh, V.M.S.
dc.contributor.authorOng, B.K.C.
dc.contributor.authorChow, A.W.L.
dc.contributor.authorSeet, R.C.S.
dc.date.accessioned2011-09-27T05:14:58Z
dc.date.available2011-09-27T05:14:58Z
dc.date.issued2006
dc.identifier.citationLim, E.C.-H., Oh, V.M.S., Ong, B.K.C., Chow, A.W.L., Seet, R.C.S. (2006). Where has all the botox gone? (How) will we ever learn... Using monoclonal antibodies to track botulinum toxin. Medical Hypotheses 67 (3) : 440-446. ScholarBank@NUS Repository. https://doi.org/10.1016/j.mehy.2006.03.014
dc.identifier.issn03069877
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/26723
dc.description.abstractBotulinum toxin (BTX) is an important therapeutic tool in the treatment of overactive skeletal and smooth muscles, as well as hypersecretory and painful disorders. Despite advances in our understanding of how BTX works, much remains to be elucidated, such as how BTX ameliorates pain, how it produces weakness remote from the site of injection and the fate of the heavy and light chain components of the BTX molecule following endocytosis into the presynaptic membrane. BTX, conjugated to radionuclides, allows investigators to track the molecule both in vitro and in vivo. However, altering the BTX molecule may cause structural changes or pharmacokinetic and pharmacodynamic alterations, and disrupt its normal action. We propose instead to bind the biomarkers (appropriate dyes, radionuclides or MRI contrast agents) to monoclonal antibodies directed against either heavy or light chain components of BTX, thus allowing administration of native (i.e. unaltered) BTX. © 2006 Elsevier Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.mehy.2006.03.014
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentMEDICINE
dc.description.doi10.1016/j.mehy.2006.03.014
dc.description.sourcetitleMedical Hypotheses
dc.description.volume67
dc.description.issue3
dc.description.page440-446
dc.identifier.isiut000239465700003
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