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Title: The Retinal Vasculature as a Fractal: Methodology, Reliability, and Relationship to Blood Pressure
Authors: Liew, G.
Wang, J.J.
Mitchell, P.
Taylor, B.
Cheung, N.
Tikellis, G.
Wong, T.Y. 
Zhang, Y.P.
Hsu, W. 
Lee, M.L. 
Issue Date: 2008
Citation: Liew, G., Wang, J.J., Mitchell, P., Taylor, B., Cheung, N., Tikellis, G., Wong, T.Y., Zhang, Y.P., Hsu, W., Lee, M.L. (2008). The Retinal Vasculature as a Fractal: Methodology, Reliability, and Relationship to Blood Pressure. Ophthalmology 115 (11). ScholarBank@NUS Repository.
Abstract: Objective: Fractals represent a type of derived geometric pattern that permits the characterization of the branching pattern of retinal vessels. We examined a new semiautomated method to measure retinal vessel fractals. Design: Methodology study. Participants: Three hundred randomly selected participants from the population-based Blue Mountains Eye Study. Methods: We developed a semiautomated computer program to measure the fractal dimension (Df) of the retinal vessels from digitized images of disk-centered retinal photographs. Two trained graders masked to participant characteristics measured Df of right eye images of participants. Reliability was determined by repeat grading of the images from 60 participants, and association with systolic and diastolic blood pressure was examined in all 300 participants. Main Outcome Measure: Df of the retinal vessels. Results: Mean Df was 1.437 with a standard deviation of 0.025. Intragrader and intergrader reliability estimates were high with intraclass correlation ranging from 0.93 to 0.95. Df was inversely correlated with age (r = -0.42, P = 0.001) and systolic blood pressure (r = -0.29, P<0.0001). After adjustment for age and sex, mean Df was significantly lower in participants with than without hypertension (Df difference 0.01, P = 0.02). Conclusions: The Df of the retinal vessels can be reliably measured from photographs and shows a strong inverse correlation with blood pressure. These data suggest that the Df may be a measure of early microvascular alterations from elevated blood pressure. Further studies to examine the systemic and ocular correlates of the Df of the retinal vessels are needed. Financial Disclosure(s): The authors have no proprietary or commercial interest in any materials discussed in this article. © 2008 American Academy of Ophthalmology.
Source Title: Ophthalmology
ISSN: 01616420
DOI: 10.1016/j.ophtha.2008.05.029
Appears in Collections:Staff Publications

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