Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.preteyeres.2009.10.001
DC FieldValue
dc.titlePolypoidal choroidal vasculopathy and neovascular age-related macular degeneration: Same or different disease?
dc.contributor.authorLaude, A.
dc.contributor.authorCackett, P.D.
dc.contributor.authorVithana, E.N.
dc.contributor.authorYeo, I.Y.
dc.contributor.authorWong, D.
dc.contributor.authorWong, T.Y.
dc.contributor.authorAung, T.
dc.contributor.authorKoh, A.H.
dc.date.accessioned2011-09-26T09:05:59Z
dc.date.available2011-09-26T09:05:59Z
dc.date.issued2010
dc.identifier.citationLaude, A., Cackett, P.D., Vithana, E.N., Yeo, I.Y., Wong, D., Wong, T.Y., Aung, T., Koh, A.H. (2010). Polypoidal choroidal vasculopathy and neovascular age-related macular degeneration: Same or different disease?. Progress in Retinal and Eye Research 29 (1) : 19-29. ScholarBank@NUS Repository. https://doi.org/10.1016/j.preteyeres.2009.10.001
dc.identifier.issn13509462
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/26566
dc.description.abstractNeovascular age-related macular degeneration (nAMD) is the commonest cause of severe visual impairment in older adults in Caucasian white populations. Polypoidal choroidal vasculopathy (PCV) has been described as a separate clinical entity differing from nAMD and other macular diseases associated with subretinal neovascularization. It remains controversial as to whether or not PCV represents a sub-type of nAMD. This article summarizes the current literature on the clinical, pathophysiological and epidemiological features and treatment responses of PCV and compares this condition to nAMD. Patients with PCV are younger and more likely Asians, and eyes with PCV lack drusen, often present with serosanguinous maculopathy or hemorrhagic pigment epithelial detachment, and have differing responses to photodynamic therapy and anti-vascular endothelial growth factor (VEGF) agents. There are also significant differences in angiographic and optical coherence tomography features between PCV and nAMD. Histopathological studies suggest differences in the anatomical details of the associated vascular abnormalities in the retina and choroids and the relative role of VEGF. There is emerging evidence of common molecular genetic determinants involving complement pathway and common environmental risk factors (e.g. smoking). Such information could further assist clinicians involved in the care of elderly patients with these conditions. © 2009 Elsevier Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.preteyeres.2009.10.001
dc.sourceScopus
dc.subjectChoroidal neovascularization
dc.subjectComplement factor H
dc.subjectIndocyanine green angiography
dc.subjectNeovascular age-related macular degeneration
dc.subjectOptical coherence tomography
dc.subjectPolypoidal choroidal vasculopathy
dc.subjectSmoking
dc.subjectVascular endothelial growth factor
dc.typeReview
dc.contributor.departmentOPHTHALMOLOGY
dc.description.doi10.1016/j.preteyeres.2009.10.001
dc.description.sourcetitleProgress in Retinal and Eye Research
dc.description.volume29
dc.description.issue1
dc.description.page19-29
dc.identifier.isiut000274959500002
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

274
checked on Sep 29, 2022

WEB OF SCIENCETM
Citations

265
checked on Sep 29, 2022

Page view(s)

407
checked on Sep 22, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.