Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.ophtha.2010.01.060
DC Field | Value | |
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dc.title | Natural History of Central Retinal Vein Occlusion: An Evidence-Based Systematic Review | |
dc.contributor.author | McIntosh, R.L. | |
dc.contributor.author | Rogers, S.L. | |
dc.contributor.author | Lim, L. | |
dc.contributor.author | Cheung, N. | |
dc.contributor.author | Wang, J.J. | |
dc.contributor.author | Wong, T.Y. | |
dc.contributor.author | Mitchell, P. | |
dc.contributor.author | Kowalski, J.W. | |
dc.contributor.author | Nguyen, H.P. | |
dc.date.accessioned | 2011-09-26T09:05:47Z | |
dc.date.available | 2011-09-26T09:05:47Z | |
dc.date.issued | 2010 | |
dc.identifier.citation | McIntosh, R.L.,Rogers, S.L.,Lim, L.,Cheung, N.,Wang, J.J.,Wong, T.Y.,Mitchell, P.,Kowalski, J.W.,Nguyen, H.P. (2010). Natural History of Central Retinal Vein Occlusion: An Evidence-Based Systematic Review. Ophthalmology 117 (6). ScholarBank@NUS Repository. <a href="https://doi.org/10.1016/j.ophtha.2010.01.060" target="_blank">https://doi.org/10.1016/j.ophtha.2010.01.060</a> | |
dc.identifier.issn | 01616420 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/26546 | |
dc.description.abstract | Objective: To describe the natural history of central retinal vein occlusion (CRVO) based on the best available evidence from the literature. Clinical Relevance: Central retinal vein occlusion is a common sight-threatening retinal vascular disease. Despite the introduction of new interventions, the natural history of CRVO is unclear. Methods: Systemic review of all English language articles retrieved using a keyword search of MEDLINE, EMBASE, Current Contents, and the Cochrane Library to November 13, 2008. This was supplemented by hand-searching references of review articles published within the last 5 years. Two investigators independently identified all relevant observational studies evaluating the natural history of RVO and all clinical trials evaluating interventions for CRVO; an untreated control arm was included. Results: Of 5966 citations retrieved, 53 studies were reviewed, providing 3271 eyes with CRVO for analysis of its natural history. Visual acuity (VA) was generally poor at baseline (<20/40) and decreased further over time. Although 6 studies reported an improvement in VA, none of these improvements resulted in VA better than 20/40. Up to 34% of eyes with nonischemic CRVO converted to ischemic CRVO over a 3-year period. In ischemic CRVO cases, neovascular glaucoma developed in at least 23% of eyes within 15 months. In nonischemic CRVO cases, macular edema resolved in approximately 30% of eyes over time, and subsequent neovascular glaucoma was rare. Conclusions: Untreated eyes with CRVO generally had poor VA, which declined further over time. One quarter of eyes with nonischemic CRVO converted to ischemic CRVO. Financial Disclosure(s): Proprietary or commercial disclosure may be found after the references. © 2010 American Academy of Ophthalmology. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.ophtha.2010.01.060 | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | OPHTHALMOLOGY | |
dc.description.doi | 10.1016/j.ophtha.2010.01.060 | |
dc.description.sourcetitle | Ophthalmology | |
dc.description.volume | 117 | |
dc.description.issue | 6 | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Staff Publications |
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