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|Title:||C-reactive protein, gamma-glutamyltransferase and type 2 diabetes in a Chinese population||Authors:||Wen, J.
|Issue Date:||2010||Citation:||Wen, J., Guo, Y., Liu, X., Liang, Y., Wang, F., Duan, X., Wang, N., Sun, L., Wong, T.Y. (2010). C-reactive protein, gamma-glutamyltransferase and type 2 diabetes in a Chinese population. Clinica Chimica Acta 411 (3-4) : 198-203. ScholarBank@NUS Repository. https://doi.org/10.1016/j.cca.2009.11.002||Abstract:||Background: We studied the association of C-reactive protein (CRP), gamma-glutamyltransferase (GGT) and type 2 diabetes in Chinese. Method: A population-based cross-sectional study. Results: CRP and GGT levels were significantly higher in participants with diabetes than in those without (P < 0.001). Higher CRP levels were positively associated with prevalent type 2 diabetes after adjustment for age, sex, smoking, alcohol consumption, physical activity, family history of diabetes, body mass index, waist circumference, waist/hip ratio, education, systolic blood pressure, triglycerides, high density lipoprotein cholesterol, use of antihypertensive drugs, aspirin and lipid-lowering agents, with multivariable odds ratios (OR) of 1.55 (95% confidence interval (CI), 1.05-2.27, P trend = 0.005, comparing quartile 4 to quartile 1). However, after further adjustment for GGT, the association was completely attenuated (fourth quartile OR 1.23, 95% CI, 0.83-1.82, P trend = 0.127). Moreover, the association of CRP and prevalent type 2 diabetes was stronger in subjects with GGT values above the median than in those with GGT values below the median. Increasing serum GGT quartiles were positively associated with prevalent type 2 diabetes after adjustment for potential confounding variables (P for trend < 0.001). Conclusion: CRP may not be an independent risk factor for type 2 diabetes, at least in Chinese people. Crown Copyright © 2009.||Source Title:||Clinica Chimica Acta||URI:||http://scholarbank.nus.edu.sg/handle/10635/26533||ISSN:||00098981||DOI:||10.1016/j.cca.2009.11.002|
|Appears in Collections:||Staff Publications|
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