Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jacc.2007.03.029
DC FieldValue
dc.titleRetinal Arteriolar Narrowing and Left Ventricular Remodeling. The Multi-Ethnic Study of Atherosclerosis
dc.contributor.authorCheung, N.
dc.contributor.authorIslam, F.M.A.
dc.contributor.authorWong, T.Y.
dc.contributor.authorBluemke, D.A.
dc.contributor.authorKlein, R.
dc.contributor.authorKlein, B.E.K.
dc.contributor.authorSharrett, A.R.
dc.contributor.authorCotch, M.F.
dc.contributor.authorCriqui, M.H.
dc.date.accessioned2011-09-26T09:04:39Z
dc.date.available2011-09-26T09:04:39Z
dc.date.issued2007
dc.identifier.citationCheung, N., Islam, F.M.A., Wong, T.Y., Bluemke, D.A., Klein, R., Klein, B.E.K., Sharrett, A.R., Cotch, M.F., Criqui, M.H. (2007). Retinal Arteriolar Narrowing and Left Ventricular Remodeling. The Multi-Ethnic Study of Atherosclerosis. Journal of the American College of Cardiology 50 (1) : 48-55. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jacc.2007.03.029
dc.identifier.issn07351097
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/26441
dc.description.abstractObjectives: This study sought to examine the relationships of retinal vascular signs with left ventricular (LV) mass, volume, and concentric remodeling. Background: Microvascular disease, reflected as retinopathy lesions, has been shown to predict clinical congestive heart failure. Whether these retinal vascular changes are related to early structural alterations and remodeling of the heart in asymptomatic individuals is unknown. Methods: A cross-sectional, population-based study of 4,593 participants ages 45 to 85 years, free of clinical cardiovascular disease. Retinal vascular calibers and retinopathy were graded from retinal photographs according to standardized protocols. The LV mass and volume were measured from cardiac magnetic resonance imaging. Extent of LV concentric remodeling was determined by the ratio of LV mass to end-diastolic volume (M/V ratio). Results: After controlling for age, gender, race, center, past and current systolic blood pressure, body mass index, smoking, antihypertensive medications, diabetes, diabetes duration, glycosylated hemoglobin, lipid profile, and C-reactive protein, narrower retinal arteriolar caliber was associated with concentric (highest quintile of M/V ratio) remodeling (odds ratio [OR] 2.06, 95% confidence interval 1.57 to 2.70). This association was seen in men and women, and was present even in those without diabetes, without hypertension, and without significant coronary calcification. In multivariate analysis, the presence of retinopathy (OR 1.31, 95% confidence interval 1.08 to 1.61) was also associated with concentric remodeling. Conclusions: Narrower retinal arteriolar caliber is associated with LV concentric remodeling independent of traditional risk factors and coronary atherosclerotic burden, supporting the hypothesis that microvascular disease may contribute to cardiac remodeling. © 2007 American College of Cardiology Foundation.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.jacc.2007.03.029
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentOPHTHALMOLOGY
dc.description.doi10.1016/j.jacc.2007.03.029
dc.description.sourcetitleJournal of the American College of Cardiology
dc.description.volume50
dc.description.issue1
dc.description.page48-55
dc.identifier.isiut000247750600008
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

83
checked on Jul 12, 2019

WEB OF SCIENCETM
Citations

77
checked on Jul 12, 2019

Page view(s)

115
checked on Jun 22, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.