Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.mad.2006.12.008
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dc.titleAge-related changes in mitochondrial function and antioxidative enzyme activity in fischer 344 rats
dc.contributor.authorMeng, Q.
dc.contributor.authorWong, Y.T.
dc.contributor.authorChen, J.
dc.contributor.authorRuan, R.
dc.date.accessioned2011-09-19T07:39:36Z
dc.date.available2011-09-19T07:39:36Z
dc.date.issued2007
dc.identifier.citationMeng, Q., Wong, Y.T., Chen, J., Ruan, R. (2007). Age-related changes in mitochondrial function and antioxidative enzyme activity in fischer 344 rats. Mechanisms of Ageing and Development 128 (3) : 286-292. ScholarBank@NUS Repository. https://doi.org/10.1016/j.mad.2006.12.008
dc.identifier.issn00476374
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/26294
dc.description.abstractWe have previously reported the changes of mitochondrial function and/or antioxidative enzyme efficiency in a few organs of rats as a result of aging. However, there is a further need to reach a conclusion about their interactions in biological functions based on other evaluation tips like the usage of advanced methods and the exploring of crucial biochemical parameters. Therefore, we investigated the mitochondrial inner membrane functional integrity by the analysis of respiration control ratio and membrane potential in the liver and brain of young (8 months) and old (26 months) Fischer 344 rats. The disintegration of mitochondrial membrane integrity was determined higher in the liver of old rats than that of young rats. This was well correlated with the decrease of total superoxide dismutase (SOD), Cu/Zn-SOD, Mn-SOD and glutathione peroxidase activities in most of the organs, except for the increase of catalase activity in heart of old rats. Similarly, the protein expressions of these enzymes were down regulated in the liver and kidney of old rats. Taken together, we suggest that the mitochondrial malfunction in old rats is associated with the decrease of antioxidative enzyme efficiency. And the data are also discussed with changes in the results from inter-laboratories. © 2007 Elsevier Ireland Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.mad.2006.12.008
dc.sourceScopus
dc.subjectAging
dc.subjectAntioxidative enzyme
dc.subjectMitochondrial membrane potential
dc.subjectReactive oxygen species
dc.subjectRespiratory control ratio
dc.typeArticle
dc.contributor.departmentOTOLARYNGOLOGY
dc.description.doi10.1016/j.mad.2006.12.008
dc.description.sourcetitleMechanisms of Ageing and Development
dc.description.volume128
dc.description.issue3
dc.description.page286-292
dc.identifier.isiut000244793800006
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