Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.neulet.2005.11.060
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dc.titleSupraspinal nocistatin and its amide derivative antagonize the hyperalgesic effects of nociceptin in mice
dc.contributor.authorLiu, E.H.C.
dc.contributor.authorTachibana, S.
dc.contributor.authorNishiuchi, Y.
dc.contributor.authorKimura, T.
dc.date.accessioned2011-09-19T04:47:42Z
dc.date.available2011-09-19T04:47:42Z
dc.date.issued2006
dc.identifier.citationLiu, E.H.C., Tachibana, S., Nishiuchi, Y., Kimura, T. (2006). Supraspinal nocistatin and its amide derivative antagonize the hyperalgesic effects of nociceptin in mice. Neuroscience Letters 397 (1-2) : 59-63. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neulet.2005.11.060
dc.identifier.issn03043940
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/26192
dc.description.abstractNocistatin (NST) and nociceptin (NCP)/orphanin FQ are new neuropeptides derived from the same precursor molecule, and which are involved in pain transmission. Nocistatin has been shown to antagonize several effects of nociceptin by acting on a different receptor. We examined the effects of supraspinal nocistatin and nocistatin amide, and their interaction with nociceptin on nociceptive behavior in mice, using hotplate response times. We found that both nocistatin and nocistatin amide did not change the response time compared to control mice, whereas increasing doses of nociceptin caused progressive shortening of response times. Nocistatin and nocistatin amide were both able to antagonize the hyperalgesic effect of nociceptin. The effect of nocistatin amide was longer lasting and more potent, suggesting that the C-terminal free carboxyl group of nocistatin is not necessary for its biological activity, and that the amide derivative may be more biologically stable. © 2005 Elsevier Ireland Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.neulet.2005.11.060
dc.sourceScopus
dc.subjectHotplate
dc.subjectHyperalgesia
dc.subjectNociceptin
dc.subjectNocistatin
dc.typeArticle
dc.contributor.departmentANAESTHESIA
dc.description.doi10.1016/j.neulet.2005.11.060
dc.description.sourcetitleNeuroscience Letters
dc.description.volume397
dc.description.issue1-2
dc.description.page59-63
dc.identifier.isiut000236241700013
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