Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/26100
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dc.titleCD137 enhances monocyte-ICAM-1 interactions in an E-selectin-dependent manner under flow conditions
dc.contributor.authorQuek, B.Z.
dc.contributor.authorLim, Y.C.
dc.contributor.authorLin, J.H.R.
dc.contributor.authorTan, T.E.
dc.contributor.authorSchwarz, H.
dc.contributor.authorChan, J.
dc.contributor.authorBiswas, A.
dc.date.accessioned2011-09-15T08:43:34Z
dc.date.available2011-09-15T08:43:34Z
dc.date.issued2010
dc.identifier.citationQuek, B.Z., Lim, Y.C., Lin, J.H.R., Tan, T.E., Schwarz, H., Chan, J., Biswas, A. (2010). CD137 enhances monocyte-ICAM-1 interactions in an E-selectin-dependent manner under flow conditions. Molecular Immunology 47 (9) : 1839-1847. ScholarBank@NUS Repository.
dc.identifier.issn01615890
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/26100
dc.description.abstractExpression of CD137, a member of the tumor necrosis factor receptor family, is inducible on vascular endothelial cells by proinflammatory stimuli. Its ligand is expressed as a transmembrane protein on the surface of monocytes, and transmits activating signals into monocytes (reverse signaling) inducing monocyte migration. These findings led to the hypothesis that CD137 expression on activated endothelial cells facilitates recruitment of monocytes into inflammatory tissues including atherosclerotic lesions. Data from this study demonstrate that CD137 expression is inducible on endothelial cells by TNF stimulation. Recombinant CD137 protein and CD137 expressed on activated endothelial cells enhance ICAM-1-mediated adhesion of monocytes under defined flow conditions in vitro. CD137 seems not to play a role in tethering of monocytes since this activity is completely E-selectin-dependent. In addition, LFA-1 affinity and clustering on monocytic cells is enhanced by CD137. In summary, CD137 expression is induced on vascular endothelial cells by proinflammatory mediators and strengthens ICAM-1 and LFA-1-mediated adhesion of monocytes. These data support a role for CD137 in the recruitment of monocytes to inflammatory tissues. © 2009 Elsevier Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.molimm.2009.11.010
dc.sourceScopus
dc.subjectCD137
dc.subjectInflammation
dc.subjectIntegrin
dc.subjectMonocyte
dc.subjectRecruitment
dc.typeArticle
dc.contributor.departmentRESTORATIVE DENTISTRY
dc.contributor.departmentOBSTETRICS & GYNAECOLOGY
dc.contributor.departmentPHYSIOLOGY
dc.description.sourcetitleMolecular Immunology
dc.description.volume47
dc.description.issue9
dc.description.page1839-1847
dc.identifier.isiut000278262700022
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