Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.chroma.2007.10.015
DC FieldValue
dc.titleApplication of micro-solid-phase extraction for the determination of persistent organic pollutants in tissue samples
dc.contributor.authorBasheer, C.
dc.contributor.authorYin, M.
dc.contributor.authorLee, H.K.
dc.contributor.authorNarasimhan, K.
dc.contributor.authorZhao, C.
dc.contributor.authorChoolani, M.
dc.date.accessioned2011-09-15T08:43:31Z
dc.date.available2011-09-15T08:43:31Z
dc.date.issued2008
dc.identifier.citationBasheer, C., Yin, M., Lee, H.K., Narasimhan, K., Zhao, C., Choolani, M. (2008). Application of micro-solid-phase extraction for the determination of persistent organic pollutants in tissue samples. Journal of Chromatography A 1186 (1-2) : 358-364. ScholarBank@NUS Repository. https://doi.org/10.1016/j.chroma.2007.10.015
dc.identifier.issn00219673
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/26097
dc.description.abstractA novel, simple and efficient method for determining persistent organic pollutants (POPs) in tissue samples has been developed. This technique involves the use of simultaneous microwave-assisted digestion (MAD) and micro-solid-phase extraction (μ-SPE), in which the sorbent is held within a propylene membrane envelope, with gas chromatographic-mass spectrometric (GC-MS) analysis. The POPs studied included eleven organochlorine pesticides and five polychlorinated biphenyl congeners. Optimization of the MAD-μ-SPE parameters was performed. The relative standard deviations (RSDs) of the method ranged from 0.14 to 12.7%. Correlation coefficients up to 0.9999 were obtained across a concentration range of 1.25-50 ng g-1. The method detection limits for POPs ranged from 0.002 to 0.009 ng g-1. A preliminary study applying the MAD-μ-SPE procedure to human ovarian cancer tissue showed that it was capable of detecting the presence of a wide spectrum of different POPs in benign and malignant tumors. © 2007 Elsevier B.V. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.chroma.2007.10.015
dc.sourceScopus
dc.subjectMicro-solid phase extraction
dc.subjectMicrowave-assisted extraction
dc.subjectOvarian cancer
dc.subjectPersistent organic pollutants
dc.typeArticle
dc.contributor.departmentOBSTETRICS & GYNAECOLOGY
dc.contributor.departmentCHEMISTRY
dc.description.doi10.1016/j.chroma.2007.10.015
dc.description.sourcetitleJournal of Chromatography A
dc.description.volume1186
dc.description.issue1-2
dc.description.page358-364
dc.identifier.isiut000254884700030
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