Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ejphar.2006.02.001
DC FieldValue
dc.titlePossible role for the novel gasotransmitter hydrogen sulphide in erectile dysfunction - A pilot study
dc.contributor.authorSrilatha, B.
dc.contributor.authorAdaikan, P.G.
dc.contributor.authorMoore, P.K.
dc.date.accessioned2011-09-15T08:43:05Z
dc.date.available2011-09-15T08:43:05Z
dc.date.issued2006
dc.identifier.citationSrilatha, B., Adaikan, P.G., Moore, P.K. (2006). Possible role for the novel gasotransmitter hydrogen sulphide in erectile dysfunction - A pilot study. European Journal of Pharmacology 535 (1-3) : 280-282. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ejphar.2006.02.001
dc.identifier.issn00142999
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/26071
dc.description.abstractPenile erectile tissue is a highly vascularised smooth muscle which hitherto has been an unexplored target for the neuromodulatory effect of hydrogen sulphide. In this study, intracavernous injection of sodium hydrogen sulphide to primates resulted in significant increases in penile length and cavernous pressure. In another set of experiments, administration of dl-propargylglycine (inhibitor of cystathionine γ-lyase) to rats resulted in significant reduction in cavernous nerve stimulation-evoked perfusion pressure. Our pilot experiment suggests a possible role for endogenous hydrogen sulphide in erectile physiopharmacology through facilitation of nerve-mediated penile tumescence; this is confirmed by the inhibitory effect of propargylglycine on the proerectile pathway. © 2006 Elsevier B.V. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.ejphar.2006.02.001
dc.sourceScopus
dc.subject(Rat)
dc.subjectCorpus cavernosum
dc.subjectErectile dysfunction
dc.subjectHydrogen sulphide
dc.subjectIntracavernous pressure
dc.subjectPrimate
dc.typeArticle
dc.contributor.departmentOBSTETRICS & GYNAECOLOGY
dc.contributor.departmentPHARMACOLOGY
dc.description.doi10.1016/j.ejphar.2006.02.001
dc.description.sourcetitleEuropean Journal of Pharmacology
dc.description.volume535
dc.description.issue1-3
dc.description.page280-282
dc.identifier.isiut000236652700037
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