Please use this identifier to cite or link to this item:
|Title:||Possible role for the novel gasotransmitter hydrogen sulphide in erectile dysfunction - A pilot study||Authors:||Srilatha, B.
|Issue Date:||2006||Citation:||Srilatha, B., Adaikan, P.G., Moore, P.K. (2006). Possible role for the novel gasotransmitter hydrogen sulphide in erectile dysfunction - A pilot study. European Journal of Pharmacology 535 (1-3) : 280-282. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ejphar.2006.02.001||Abstract:||Penile erectile tissue is a highly vascularised smooth muscle which hitherto has been an unexplored target for the neuromodulatory effect of hydrogen sulphide. In this study, intracavernous injection of sodium hydrogen sulphide to primates resulted in significant increases in penile length and cavernous pressure. In another set of experiments, administration of dl-propargylglycine (inhibitor of cystathionine γ-lyase) to rats resulted in significant reduction in cavernous nerve stimulation-evoked perfusion pressure. Our pilot experiment suggests a possible role for endogenous hydrogen sulphide in erectile physiopharmacology through facilitation of nerve-mediated penile tumescence; this is confirmed by the inhibitory effect of propargylglycine on the proerectile pathway. © 2006 Elsevier B.V. All rights reserved.||Source Title:||European Journal of Pharmacology||URI:||http://scholarbank.nus.edu.sg/handle/10635/26071||ISSN:||00142999||DOI:||10.1016/j.ejphar.2006.02.001|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Apr 14, 2019
WEB OF SCIENCETM
checked on Mar 27, 2019
checked on Apr 21, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.