Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bone.2010.05.028
DC FieldValue
dc.titleAssociation between an intronic apolipoprotein E polymorphism and bone mineral density in Singaporean Chinese females
dc.contributor.authorTong, T.Y.Y.
dc.contributor.authorMok, H.P.P.
dc.contributor.authorYong, E.L.
dc.contributor.authorYong, R.Y.Y.
dc.contributor.authorChong, A.P.L.
dc.contributor.authorYap, E.P.H.
dc.contributor.authorMoochhala, S.
dc.contributor.authorGoh, V.H.H.
dc.contributor.authorLiang, S.
dc.date.accessioned2011-09-15T08:22:20Z
dc.date.available2011-09-15T08:22:20Z
dc.date.issued2010
dc.identifier.citationTong, T.Y.Y., Mok, H.P.P., Yong, E.L., Yong, R.Y.Y., Chong, A.P.L., Yap, E.P.H., Moochhala, S., Goh, V.H.H., Liang, S. (2010). Association between an intronic apolipoprotein E polymorphism and bone mineral density in Singaporean Chinese females. Bone 47 (3) : 503-510. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bone.2010.05.028
dc.identifier.issn87563282
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/26029
dc.description.abstractIntroduction: Apolipoprotein E (ApoE) is implicated in the pathogenesis of osteoporosis. Objective: To investigate possible association of the non-classical APOE gene + 113C/G (rs440446) intron 1 enhancer polymorphism with bone mineral density (BMD) in a homogeneous Chinese population in Singapore. Methods: A total of 655 volunteers, males and females, aged between 31 and 72 years, from the public participated. BMD was measured using dual-energy X-ray absorptiometry and APOE + 113C/G (rs440446) genotypes were determined by Sequenom MassARRAY system. To adjust for potential confounders, anthropometric, demographic, and lifestyle determinants were obtained, and serum lipids and E2 were measured. Results: The + 113C/G (rs440446) polymorphism within the APOE gene was associated with BMD in Chinese Singaporean females only. Females with the heterozygous CG genotype were significantly associated with reduced total, lumbar spine, and femoral neck of hip BMD, after multilevel adjustment of confounders. The association was stronger in the spine than in the hip. When females were stratified according to WHO classification for osteoporosis, those with CG and GG genotypes had increased risk (OR 3.50 and 2.22, respectively) of developing osteopenia/osteoporosis in the lumbar spine. Serum lipids did not explain the influence of APOE + 113 C/G (rs440446) on BMD. Conclusion: This study demonstrated an association between APOE + 113C/G (rs440446) polymorphism with measures of BMD in Singaporean Chinese females. © 2010 Elsevier Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.bone.2010.05.028
dc.sourceScopus
dc.subjectApolipoprotein E gene
dc.subjectBone mineral density
dc.subjectChinese
dc.subjectIntronic
dc.subjectOsteoporosis
dc.subjectPolymorphism
dc.typeArticle
dc.contributor.departmentOBSTETRICS & GYNAECOLOGY
dc.description.doi10.1016/j.bone.2010.05.028
dc.description.sourcetitleBone
dc.description.volume47
dc.description.issue3
dc.description.page503-510
dc.identifier.isiut000281464200005
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

8
checked on Mar 4, 2021

WEB OF SCIENCETM
Citations

8
checked on Feb 24, 2021

Page view(s)

248
checked on Mar 3, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.