Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.chroma.2010.01.065
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dc.titleSeparation of model mixtures of epsilon-globin positive fetal nucleated red blood cells and anucleate erythrocytes using a microfluidic device
dc.contributor.authorLee, D.
dc.contributor.authorXu, G.
dc.contributor.authorSukumar, P.
dc.contributor.authorMahyuddin, A.
dc.contributor.authorChoolani, M.
dc.date.accessioned2011-09-15T08:22:19Z
dc.date.available2011-09-15T08:22:19Z
dc.date.issued2010
dc.identifier.citationLee, D., Xu, G., Sukumar, P., Mahyuddin, A., Choolani, M. (2010). Separation of model mixtures of epsilon-globin positive fetal nucleated red blood cells and anucleate erythrocytes using a microfluidic device. Journal of Chromatography A 1217 (11) : 1862-1866. ScholarBank@NUS Repository. https://doi.org/10.1016/j.chroma.2010.01.065
dc.identifier.issn00219673
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/26028
dc.description.abstractMicrofluidic devices are capable of separating microparticles and cells. We developed and tested the efficiency of silicon cross-flow microfilters for the separation of primitive fetal nucleated red blood cells (FNRBCs) and adult anucleate red blood cell (AARBCs) from model mixtures. Stepwise improvements over three generations of device design resulted in an increasing trend in the recovery of FNRBCs. We obtained a recovery of FNRBCs (74.0 ± 6.3%, p < 0.05, n = 5) using the third generation device, with a depletion of 46.5 ± 3.2% AARBCs from the cell mixture. The purity of FNRBCs in the enriched fraction was enhanced by a factor of 1.7-fold. © 2010 Elsevier B.V. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.chroma.2010.01.065
dc.sourceScopus
dc.subjectCell separation
dc.subjectEpsilon-globin
dc.subjectFNRBCs
dc.subjectMicrofluidic device
dc.subjectSilicon cross-flow filter
dc.typeArticle
dc.contributor.departmentOBSTETRICS & GYNAECOLOGY
dc.description.doi10.1016/j.chroma.2010.01.065
dc.description.sourcetitleJournal of Chromatography A
dc.description.volume1217
dc.description.issue11
dc.description.page1862-1866
dc.identifier.isiut000275353800018
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