Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.phytochem.2007.03.001
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dc.titleTaxonomic, genetic, chemical and estrogenic characteristics of Epimedium species
dc.contributor.authorShen, P.
dc.contributor.authorGong, Y.
dc.contributor.authorYong, E.L.
dc.contributor.authorGuo, B.L.
dc.contributor.authorHong, D.Y.Q.
dc.contributor.authorHong, Y.
dc.date.accessioned2011-09-15T08:22:16Z
dc.date.available2011-09-15T08:22:16Z
dc.date.issued2007
dc.identifier.citationShen, P., Gong, Y., Yong, E.L., Guo, B.L., Hong, D.Y.Q., Hong, Y. (2007). Taxonomic, genetic, chemical and estrogenic characteristics of Epimedium species. Phytochemistry 68 (10) : 1448-1458. ScholarBank@NUS Repository. https://doi.org/10.1016/j.phytochem.2007.03.001
dc.identifier.issn00319422
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/26024
dc.description.abstractTo understand the factors contributing to estrogenic properties of extracts from the genus Epimedium L. (Berberidaceae), we performed taxonomic, genetic and chemical characterization on 37 specimens from 18 species and related these to estrogen receptor (ERα and ERβ) bioactivity, as measured by reporter genes in stable human cells. Boot strap values derived from amplified fragment length polymorphisms indicated that specimens of E. koreanum, E. brevicornum, E. myrianthum, E. leishanense, and E. membranaceum were genetically distinct and this was supported by their very similar ERα activities. In contrast, specimens from E. pubescens and E. sagittatum were diverse both genetically, chemically and in terms of ERα and ERβ bioactivities. Strikingly, a genetic cluster comprising six rare Epimedium species exhibited strongest ERα and ERβ activity, and this bioactivity was positively correlated with content of trace flavonoid aglycones (kaempferol, apigenin, quercetin, luteolin and breviflavone B). In contrast, there was no association between estrogenic activity and the major flavonol glycoside constituents (icariin and epimedin A-C). Although they exhibited equally strong ERα and ERβ activity, E. koreanum can be clearly differentiated from E. pubescens and E. brevicornum by genetic distance and its significantly lower content of epimedin C. Our morphologic, genetic, chemical and bioactivity profiling provide the basis for the production of extracts with reproducible estrogenic properties. Such reproducibility will be critical for the standardization of Epimedium-based products. © 2007 Elsevier Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.phytochem.2007.03.001
dc.sourceScopus
dc.subjectBerberidaceae
dc.subjectChemical
dc.subjectEpimedium species
dc.subjectEstrogenic activity
dc.subjectGenetic
dc.subjectTaxonomy
dc.typeArticle
dc.contributor.departmentOBSTETRICS & GYNAECOLOGY
dc.description.doi10.1016/j.phytochem.2007.03.001
dc.description.sourcetitlePhytochemistry
dc.description.volume68
dc.description.issue10
dc.description.page1448-1458
dc.identifier.isiut000246868900014
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