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|Title:||Preparation and evaluation of calixarene-capped β-cyclodextrin-bonded silica particles as chiral stationary phase for high-performance liquid chromatography||Authors:||Thamarai, Chelvi S.K.
Chiral stationary phase
High-performance liquid chromatography
|Issue Date:||2008||Citation:||Thamarai, Chelvi S.K., Yong, E.L., Gong, Y. (2008). Preparation and evaluation of calixarene-capped β-cyclodextrin-bonded silica particles as chiral stationary phase for high-performance liquid chromatography. Journal of Chromatography A 1203 (1) : 54-58. ScholarBank@NUS Repository. https://doi.org/10.1016/j.chroma.2008.07.021||Abstract:||Calixarene-capped [3-(2-O-β-cyclodextrin)-2-hydroxypropoxy]propylsilyl-appended silica particles (C4CD-HPS), a new type of substituted β-cyclodextrin-bonded chiral stationary phase (CSP) for high-performance liquid chromatography (HPLC), have been synthesized by treatment of bromoacetate-substituted [3-(2-O-β-cyclodextrin)-2-hydroxypropoxy]propylsilyl-appended silica particles (BACD-HPS) with calixarene oxyanions in anhydrous N-methyl-2-pyrrolidone. The synthetic stationary phase is characterized by means of elemental analysis. This new type of CSP has a chiral selector with two recognition sites: calixarene and β-cyclodextrin (β-CD). The chromatographic behavior of C4CD-HPS was studied with several disubstituted benzenes and some chiral drug compounds under reversed-phase conditions. The results show that C4CD-HPS has excellent selectivity for the separation of aromatic positional isomers and enantiomers of chiral compounds due to the cooperative functioning of calixarenes and β-CDs. © 2008 Elsevier B.V. All rights reserved.||Source Title:||Journal of Chromatography A||URI:||http://scholarbank.nus.edu.sg/handle/10635/26022||ISSN:||00219673||DOI:||10.1016/j.chroma.2008.07.021|
|Appears in Collections:||Staff Publications|
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