Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.contraception.2008.07.012
DC FieldValue
dc.titleEffects of Mirena (levonorgestrel-releasing intrauterine system) and Ortho Gynae T380 intrauterine copper device on lipid metabolism-a randomized comparative study
dc.contributor.authorNg, Y.W.
dc.contributor.authorSingh, K.
dc.contributor.authorLiang, S.
dc.date.accessioned2011-09-15T08:21:38Z
dc.date.available2011-09-15T08:21:38Z
dc.date.issued2009
dc.identifier.citationNg, Y.W., Singh, K., Liang, S. (2009). Effects of Mirena (levonorgestrel-releasing intrauterine system) and Ortho Gynae T380 intrauterine copper device on lipid metabolism-a randomized comparative study. Contraception 79 (1) : 24-28. ScholarBank@NUS Repository. https://doi.org/10.1016/j.contraception.2008.07.012
dc.identifier.issn00107824
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/25986
dc.description.abstractBackground: This study aims to assess the effects of levonorgestrel-releasing intrauterine system (LNG-IUS) on lipid metabolism in an Asian population using Ortho Gynae T380 copper containing (nonhormonal) intrauterine device (IUD) as a control. Study Design: Ninety-two healthy women requesting IUD for contraception were randomly allocated to the two groups and were followed up at 6-, 12- and 18-month intervals. Serum concentrations of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), apolipoprotein A-I (Apo A-I) and apolipoprotein B were measured pre insertion and at each visit following insertion. Results: There was a marginally significant reduction in TC level in the LNG-IUS group. HDL-C showed a significant reduction in the LNG-IUS group at 6 months but reverted back to its preinsertion value by 1 year. TG, LDL-C and the cholesterol ratios remained stable. Levels of Apo A-I and B also showed no significant reduction in both groups, and their ratios remained stable and insignificant. Conclusion: In this randomized comparative study among our local Asian population, it is assuring to note that the LNG-IUS does not have any adverse effects on lipid metabolism. © 2009 Elsevier Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.contraception.2008.07.012
dc.sourceScopus
dc.subjectLipid metabolism
dc.subjectLNG-IUS
dc.subjectProgestins
dc.typeArticle
dc.contributor.departmentOBSTETRICS & GYNAECOLOGY
dc.description.doi10.1016/j.contraception.2008.07.012
dc.description.sourcetitleContraception
dc.description.volume79
dc.description.issue1
dc.description.page24-28
dc.identifier.isiut000261721000004
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