Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.contraception.2008.07.012
Title: Effects of Mirena (levonorgestrel-releasing intrauterine system) and Ortho Gynae T380 intrauterine copper device on lipid metabolism-a randomized comparative study
Authors: Ng, Y.W.
Singh, K. 
Liang, S.
Keywords: Lipid metabolism
LNG-IUS
Progestins
Issue Date: 2009
Citation: Ng, Y.W., Singh, K., Liang, S. (2009). Effects of Mirena (levonorgestrel-releasing intrauterine system) and Ortho Gynae T380 intrauterine copper device on lipid metabolism-a randomized comparative study. Contraception 79 (1) : 24-28. ScholarBank@NUS Repository. https://doi.org/10.1016/j.contraception.2008.07.012
Abstract: Background: This study aims to assess the effects of levonorgestrel-releasing intrauterine system (LNG-IUS) on lipid metabolism in an Asian population using Ortho Gynae T380 copper containing (nonhormonal) intrauterine device (IUD) as a control. Study Design: Ninety-two healthy women requesting IUD for contraception were randomly allocated to the two groups and were followed up at 6-, 12- and 18-month intervals. Serum concentrations of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), apolipoprotein A-I (Apo A-I) and apolipoprotein B were measured pre insertion and at each visit following insertion. Results: There was a marginally significant reduction in TC level in the LNG-IUS group. HDL-C showed a significant reduction in the LNG-IUS group at 6 months but reverted back to its preinsertion value by 1 year. TG, LDL-C and the cholesterol ratios remained stable. Levels of Apo A-I and B also showed no significant reduction in both groups, and their ratios remained stable and insignificant. Conclusion: In this randomized comparative study among our local Asian population, it is assuring to note that the LNG-IUS does not have any adverse effects on lipid metabolism. © 2009 Elsevier Inc. All rights reserved.
Source Title: Contraception
URI: http://scholarbank.nus.edu.sg/handle/10635/25986
ISSN: 00107824
DOI: 10.1016/j.contraception.2008.07.012
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