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Title: Development of potential antiviral strategy against coxsackievirus B4
Authors: Tan, E.L. 
Wong, A.P.Y.
Poh, C.L.
Keywords: 19-mer siRNAs
Coxsackievirus B4
Potential antiviral strategy
RNA interference (RNAi)
Type 1 insulin dependent diabetes mellitus (IDDM)
Viral inhibition
Issue Date: 2010
Citation: Tan, E.L., Wong, A.P.Y., Poh, C.L. (2010). Development of potential antiviral strategy against coxsackievirus B4. Virus Research 150 (1-2) : 85-92. ScholarBank@NUS Repository.
Abstract: Coxsackievirus B4 (CVB4) can cause a broad range of diseases such as aseptic meningitis, meningoencephalitis, myocarditis, hepatitis, pancreatitis, gastroenteritis, necrotizing enterocolitis, pneumonia and sudden death in the neonates. CVB4 has also been implicated as a possible etiological agent for type 1 insulin dependent diabetes mellitus (IDDM). In this study, the possibility of RNA interference (RNAi) as a potential therapeutic approach to treat CVB4 infection was explored. The results showed that the Rhabdomyosarcoma (RD) cells treated with 19-mer siRNAs displayed high specificity against CVB4 replication without displaying any sign of target effects. The siRNA targeting the 3Cpro region of CVB4 genome was also established to be the most effective in inhibition of CVB4 replication in RD cell line in a dosage dependent manner, indicating its potential to be developed as an antiviral strategy against CVB4. © 2010 Elsevier B.V.
Source Title: Virus Research
ISSN: 01681702
DOI: 10.1016/j.virusres.2010.02.017
Appears in Collections:Staff Publications

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